Table 3 Algorithmic approach to the differential diagnosis of ovarian mucinous tumors
Study | N primary | N metastatic | Algorithm | Accuracy % | Sensitivityf % | Specificityf % | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
Seidman et al. (Ref. [3]) | 12 | 40 | ≥ 10 cm, unilateral | 90.0 | 75.0 | 94.7 | 81.8 | 92.3 |
≥ 10 cm, unilateral, excl. Signet ring cell | 83.0 | – | – | – | – | |||
Khunamorpong et al.a (Ref. [56]) | 16 | 52 | ≥ 10 cm, unilateral, excl. Signet ring cell | 83.8 | 81.3 | 84.3 | 61.9 | 93.6 |
≥ 15 cm, unilateral, excl. Signet ring cell | 83.8 | 56.3 | 92.3 | 69.2 | 87.3 | |||
Yemelyanova et al. (Ref. [57]) | 52 | 142 | ≥ 10 cm, unilateral | 83.5 | 100 | 77.5 | 61.9 | 100 |
≥ 10 cm, unilateral, excl. Signet ring cell | 87.3 | 100 | 81 | 72.2 | 100 | |||
≥ 12 cm, unilateral | 85.6 | 100 | 80.3 | 65 | 100 | |||
≥ 12 cm, unilateral, excl. Signet ring cell | 83.2 | 100 | 75.7 | 65 | 100 | |||
≥ 13 cm, unilateral | 86.1 | 98.1 | 81.7 | 66.2 | 99.1 | |||
≥ 13 cm, unilateral, excl. Signet ring cell | 84.4 | 98.1 | 78.3 | 67.1 | 98.9 | |||
Okamoto et al. (Ref. [58]) | 58c | 36 | ≥ 10 cm, unilateral | 71.3b | – | – | – | – |
DPEP1, CK7, CDX2, sized | 93.3 | |||||||
Jung et al. (Ref. [59]) | 19 | 91 | ≥ 10 cm, unilateral | 82.7 | 94.7 | 80.2 | 50 | 98.6 |
≥ 10 cm, unilateral, excl. Signet ring cell | 80.6 | 94.7 | 77.7 | 51.4 | 98.3 | |||
≥ 13 cm, unilateral | 87.3 | 78.9 | 89 | 60 | 95.3 | |||
≥ 13 cm, unilateral, excl. Signet ring cell | 84.9 | 78.9 | 86.5 | 60 | 94.1 | |||
≥ 15 cm, unilateral | 89.1 | 64.8 | 93.4 | 68.4 | 93.4 | |||
Maeda-Taniguchi et al. (Ref. 60]) | 51 | 22 | ≥ 10 cm, unilateral | 75.3 | 70.6 | 86.4 | 92.3 | 55.9 |
Hu et al. (Ref. [13]) | 47 | 18 | primary: ≥ 10 cm, unilateral, PAX8 +/− meta: PAX8 - and bilateral (any size) or unilateral < 10 cm | 86.2 | 91.5 | 72.2 | 89.6 | 87 |
≥ 10 cm, unilateral | 75.4 | – | – | – | – | |||
Hu et al. (Ref. [61]) | 61 | 68 | primary: ≥ 13 cm unless bilateral or has surface nodules meta: < 13 cm unless unilateral | 96.1 | – | – | – | – |
Simons et al. (Ref. [62]) | 735 | 1018 | algorithm based on histology (signet ring cells), laterality, size and agee | 77.1 | 59 | 90.1 | 81.1 | 75.3 |
≥ 10 cm, unilateral | 76.6 | 82.2 | 72.5 | 68.3 | 84.9 | |||
≥ 13 cm, unilateral | 77.2 | 73.6 | 79.9 | 72.5 | 80.7 |