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Table 1 Genomic alterations detected by NGS profiling of pulmonary resections from three cases

From: Next-generation sequencing facilitates differentiating between multiple primary lung cancer and intrapulmonary metastasis: a case series

Case # 1 2 3
Specimen # 1 2 1 2 3 1 2 3 4
Specimen source LUL LLL lesion #2 lesion #5 lesion #6 RUL RUL LN LUL
Tumor cell fraction 80% 40% 8% 10% 20% 80% 10% 40% 70%
Mutation
EGFR          
  L858R +         
  20in S768_D770dup   +        
  E709K       + + +  
  G719A       +   +  
  G719S          +
  L861Q          +
BRAF
  G466E    +       
  V600_K601delinsE     +      
  BRAF K601E      +     
TP53
  P278A +         
  R248W          +
  R273L       + + +  
CHEK2          +
CTNNB1 +         
ARID1A   +        
ASXL2   +        
FLT4    +       
HOXB13       +   +  
KMT2D     +      
MAP 2 K4        + +  
NF1    +       
PALB2       +   +  
PAX5       + + +  
PDGFRB +         
RB1       +    
SMARCA4 +         
TET2      +     
Amplification
CCND3          +
CDK4       +   +  
CDKN1A          +
DAXX          +
FANCE          +
GLI1       +   +  
GNAS       +    
MDM2       +   +  
NKX2–1       +   +  
NOTCH4          +
PAK1       + + +  
PIM1          +
SDHA +         
TERT +      +    
VEGFA          +
  1. NGS Next-generation sequencing, LUL Left upper lobe, LLL Left lower lobe, RUL Right upper lobe, LN Lymph nodes. +, tested positive for indicated alteration