Diagnostic Pathology

Table 1 Genomic alterations detected by NGS profiling of pulmonary resections from three cases

From: Next-generation sequencing facilitates differentiating between multiple primary lung cancer and intrapulmonary metastasis: a case series

Case #	1		2			3
Specimen #	1	2	1	2	3	1	2	3	4
Specimen source	LUL	LLL	lesion #2	lesion #5	lesion #6	RUL	RUL	LN	LUL
Tumor cell fraction	80%	40%	8%	10%	20%	80%	10%	40%	70%
Mutation
EGFR
L858R	+
20in S768_D770dup		+
E709K						+	+	+
G719A						+		+
G719S									+
L861Q									+
BRAF
G466E			+
V600_K601delinsE				+
BRAF K601E					+
TP53
P278A	+
R248W									+
R273L						+	+	+
CHEK2									+
CTNNB1	+
ARID1A		+
ASXL2		+
FLT4			+
HOXB13						+		+
KMT2D				+
MAP 2 K4							+	+
NF1			+
PALB2						+		+
PAX5						+	+	+
PDGFRB	+
RB1						+
SMARCA4	+
TET2					+
Amplification
CCND3									+
CDK4						+		+
CDKN1A									+
DAXX									+
FANCE									+
GLI1						+		+
GNAS						+
MDM2						+		+
NKX2–1						+		+
NOTCH4									+
PAK1						+	+	+
PIM1									+
SDHA	+
TERT	+					+
VEGFA									+

NGS Next-generation sequencing, LUL Left upper lobe, LLL Left lower lobe, RUL Right upper lobe, LN Lymph nodes. +, tested positive for indicated alteration

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ISSN: 1746-1596

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