Table 4 The association between cytoplasmic and endothelial CD105 expressions and clinicopathological parameters of colorectal cancer (CRC) samples (H-score) (P value; Pearson’s χ2 test)
Patients and tumor characteristics | Total samples N (%) | H-score (cut off = 26) N (%) Cytoplasmic CD105 expression | P-value | H-score (cut off = 284) N (%) Endothelial CD105 expression | P-value | ||
|---|---|---|---|---|---|---|---|
Low (≤ 26) | High (>  26) | Low (≤ 284) | High (>  284) | ||||
Number of CRC samples | 208 | 121 (58.2) | 87 (41.8) | 34 (16.3) | 174 (83.7) | ||
Mean age, years (Range) | 59 (25–88) |  |  | 0.796 |  |  | 0.358 |
  ≤ Mean age | 105 (50.5) | 62 (51.2) | 43 (49.4) |  | 20 (58.9) | 85 (48.9) |  |
  > Mean age | 103 (49.5) | 59 (48.8) | 44 (50.6) |  | 14 (41.1) | 89 (51.1) |  |
Gender | Â | Â | Â | 0.872 | Â | Â | 0.305 |
 Male | 111 (53.4) | 64 (52.9) | 47 (54.0) |  | 15 (44.1) | 96 (55.2) |  |
 Female | 97 (46.6) | 57 (47.1) | 40 (46.0) |  | 19 (55.9) | 78 (44.8) |  |
 (Male/Female) | 1.14 | 1.12 | 1.17 |  | 0.78 | 1.23 |  |
Mean tumor size (cm) | 5 | Â | Â | 0.472 | Â | Â | 0.693 |
  ≤ Mean | 145 (69.7) | 82 (67.8) | 63 (72.4) |  | 23 (67.7) | 122 (70.1) |  |
  > Mean | 63 (30.3) | 39 (32.2) | 24 (27.6) |  | 11 (32.3) | 52 (29.9) |  |
Tumor differentiation | Â | Â | Â | 0.605 | Â | Â | 0.450 |
 Well | 89 (42.8) | 55 (45.5) | 34 (39.1) |  | 12 (35.2) | 77 (44.3) |  |
 Moderate | 107 (51.4) | 60 (49.6) | 47 (54.0) |  | 21 (61.7) | 86 (49.4) |  |
 Poor | 12 (5.8) | 6 (5.0) | 6 (6.9) |  | 1 (3.1) | 11 (6.3) |  |
TNM stage | Â | Â | Â | 0.050 | Â | Â | 0.631 |
 I | 29 (13.9) | 14 (11.6) | 15 (17.2) |  | 7 (20.5) | 22 (12.6) |  |
 П | 92 (44.2) | 62 (51.2) | 30 (34.5) |  | 13 (38.2) | 79 (45.4) |  |
 III | 80 (38.5) | 43 (35.5) | 37 (42.5) |  | 13 (38.2) | 67 (38.5) |  |
 IV | 7 (3.4) | 2 (1.7) | 5 (5.7) |  | 1 (3.1) | 6 (3.4) |  |
Vascular invasion (VI) | Â | Â | Â | 0.587 | Â | Â | 0.711 |
 Present | 37 (17.8) | 23 (19.0) | 14 (16.1) |  | 6 (17.6) | 31 (17.8) |  |
 Absent | 171 (82.2) | 98 (81.0) | 73 (83.9) |  | 28 (82.4) | 143 (82.2) |  |
Lymph node invasion (LNI) | Â | Â | Â | 0.713 | Â | Â | 0.978 |
 Involved | 83 (39.9) | 47 (38.8) | 36 (41.4) |  | 14 (41.1) | 69 (39.7) |  |
 None | 125 (60.1) | 74 (61.2) | 51 (58.6) |  | 20 (58.9) | 105 (60.3) |  |
Neural invasion (NI) | Â | Â | Â | 0.371 | Â | Â | 0.241 |
 Involved | 57 (27.4) | 36 (29.8) | 21 (24.1) |  | 12 (35.2) | 45 (25.9) |  |
 None | 151 (72.6) | 85 (70.2) | 66 (75.9) |  | 22 (64.8) | 129 (74.1) |  |
Distant metastasis | Â | Â | Â | 0.662 | Â | Â | 0.438 |
 Present | 30 (14.5) | 20 (16.5) | 10 (11.5) |  | 3 (8.9) | 27 (15.5) |  |
 Absent | 91 (43.7) | 57 (47.1) | 34 (39.1) |  | 16 (47.0) | 75 (43.1) |  |
Not identified | 87 (41.8) | 44 (36.4) | 43 (49.4) | Â | 15 (44.1) | 72 (41.4) | Â |
Tumor recurrence | Â | Â | Â | 0.707 | Â | Â | 0.530 |
 Yes | 36 (17.3) | 22 (18.1) | 14 (16.1) |  | 4 (11.8) | 32 (18.4) |  |
 No | 85 (40.9) | 55 (45.5) | 30 (34.5) |  | 14 (41.2) | 71 (40.8) |  |
Not identified | 87 (41.8) | 44 (36.4) | 43 (49.4) | Â | 16 (47.0) | 71 (40.8) | Â |