|
Patients and tumor characteristics
|
Total samples N (%)
|
H-score (cut off = 26) N (%) Cytoplasmic CD105 expression
|
P-value
|
H-score (cut off = 284) N (%) Endothelial CD105 expression
|
P-value
|
|---|
|
Low (≤ 26)
|
High (> 26)
|
Low (≤ 284)
|
High (> 284)
|
|---|
|
Number of CRC samples
|
208
|
121 (58.2)
|
87 (41.8)
|
34 (16.3)
|
174 (83.7)
|
|---|
|
Mean age, years (Range)
|
59 (25–88)
| | |
0.796
| | |
0.358
|
|
≤ Mean age
|
105 (50.5)
|
62 (51.2)
|
43 (49.4)
| |
20 (58.9)
|
85 (48.9)
| |
|
> Mean age
|
103 (49.5)
|
59 (48.8)
|
44 (50.6)
| |
14 (41.1)
|
89 (51.1)
| |
|
Gender
| | | |
0.872
| | |
0.305
|
|
Male
|
111 (53.4)
|
64 (52.9)
|
47 (54.0)
| |
15 (44.1)
|
96 (55.2)
| |
|
Female
|
97 (46.6)
|
57 (47.1)
|
40 (46.0)
| |
19 (55.9)
|
78 (44.8)
| |
|
(Male/Female)
|
1.14
|
1.12
|
1.17
| |
0.78
|
1.23
| |
|
Mean tumor size (cm)
|
5
| | |
0.472
| | |
0.693
|
|
≤ Mean
|
145 (69.7)
|
82 (67.8)
|
63 (72.4)
| |
23 (67.7)
|
122 (70.1)
| |
|
> Mean
|
63 (30.3)
|
39 (32.2)
|
24 (27.6)
| |
11 (32.3)
|
52 (29.9)
| |
|
Tumor differentiation
| | | |
0.605
| | |
0.450
|
|
Well
|
89 (42.8)
|
55 (45.5)
|
34 (39.1)
| |
12 (35.2)
|
77 (44.3)
| |
|
Moderate
|
107 (51.4)
|
60 (49.6)
|
47 (54.0)
| |
21 (61.7)
|
86 (49.4)
| |
|
Poor
|
12 (5.8)
|
6 (5.0)
|
6 (6.9)
| |
1 (3.1)
|
11 (6.3)
| |
|
TNM stage
| | | |
0.050
| | |
0.631
|
|
I
|
29 (13.9)
|
14 (11.6)
|
15 (17.2)
| |
7 (20.5)
|
22 (12.6)
| |
|
П
|
92 (44.2)
|
62 (51.2)
|
30 (34.5)
| |
13 (38.2)
|
79 (45.4)
| |
|
III
|
80 (38.5)
|
43 (35.5)
|
37 (42.5)
| |
13 (38.2)
|
67 (38.5)
| |
|
IV
|
7 (3.4)
|
2 (1.7)
|
5 (5.7)
| |
1 (3.1)
|
6 (3.4)
| |
|
Vascular invasion (VI)
| | | |
0.587
| | |
0.711
|
|
Present
|
37 (17.8)
|
23 (19.0)
|
14 (16.1)
| |
6 (17.6)
|
31 (17.8)
| |
|
Absent
|
171 (82.2)
|
98 (81.0)
|
73 (83.9)
| |
28 (82.4)
|
143 (82.2)
| |
|
Lymph node invasion (LNI)
| | | |
0.713
| | |
0.978
|
|
Involved
|
83 (39.9)
|
47 (38.8)
|
36 (41.4)
| |
14 (41.1)
|
69 (39.7)
| |
|
None
|
125 (60.1)
|
74 (61.2)
|
51 (58.6)
| |
20 (58.9)
|
105 (60.3)
| |
|
Neural invasion (NI)
| | | |
0.371
| | |
0.241
|
|
Involved
|
57 (27.4)
|
36 (29.8)
|
21 (24.1)
| |
12 (35.2)
|
45 (25.9)
| |
|
None
|
151 (72.6)
|
85 (70.2)
|
66 (75.9)
| |
22 (64.8)
|
129 (74.1)
| |
|
Distant metastasis
| | | |
0.662
| | |
0.438
|
|
Present
|
30 (14.5)
|
20 (16.5)
|
10 (11.5)
| |
3 (8.9)
|
27 (15.5)
| |
|
Absent
|
91 (43.7)
|
57 (47.1)
|
34 (39.1)
| |
16 (47.0)
|
75 (43.1)
| |
|
Not identified
|
87 (41.8)
|
44 (36.4)
|
43 (49.4)
| |
15 (44.1)
|
72 (41.4)
| |
|
Tumor recurrence
| | | |
0.707
| | |
0.530
|
|
Yes
|
36 (17.3)
|
22 (18.1)
|
14 (16.1)
| |
4 (11.8)
|
32 (18.4)
| |
|
No
|
85 (40.9)
|
55 (45.5)
|
30 (34.5)
| |
14 (41.2)
|
71 (40.8)
| |
|
Not identified
|
87 (41.8)
|
44 (36.4)
|
43 (49.4)
| |
16 (47.0)
|
71 (40.8)
| |
- H-score indicates histological score
- Values in bold are statistically significant
