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Table 5 Univariate and multivariate Cox regression analyses of potential prognostic factor for disease-specific survival (DSS) in patients with colorectal cancer

From: Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

Covariate Univariate analysis Multivariate analysis
HR (95% CI) P-value HR (95% CI) P-value
Nuclear TWIST1 expression High versus Low 2.04 (1.0–4.1) 0.048 1.6 (0.8–3.4) 0.158
Tumor size (cm) 1.8 (1.0–3.5) 0.040 1.5 (0.8–2.8) 0.168
Tumor differentiation   <  0.001   0.003
Moderate versus well 2.7 (1.3–5.5) 0.004 2.4 (1.2–4.9) 0.013
Poor versus well 6.1 (2.4–15.7) <  0.001 5.0 (1.9–13.0) 0.001
Vascular invasion (VI) 0.4 (0.2–0.9) 0.030
Neural invasion (NI) 0.3 (0.1–0.5) <  0.001
Lymph node invasion (LNI) 0.5 (0.2–0.9) 0.033
Distant metastasis 0.1 (0.0–0.2) <  0.001
Tumor recurrence 0.1)0.05–0.20) <  0.001
  1. H-score indicates histological score
  2. Values in bold are statistically significant
  3. The variables with P value less than 0.05 were included in multivariable analyses
  4. HR hazard ratio, CI confidence interval