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Table 5 Univariate and multivariate Cox regression analyses of potential prognostic factor for disease-specific survival (DSS) in patients with colorectal cancer

From: Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

Covariate

Univariate analysis

Multivariate analysis

HR (95% CI)

P-value

HR (95% CI)

P-value

Nuclear TWIST1 expression High versus Low

2.04 (1.0–4.1)

0.048

1.6 (0.8–3.4)

0.158

Tumor size (cm)

1.8 (1.0–3.5)

0.040

1.5 (0.8–2.8)

0.168

Tumor differentiation

 

<  0.001

 

0.003

Moderate versus well

2.7 (1.3–5.5)

0.004

2.4 (1.2–4.9)

0.013

Poor versus well

6.1 (2.4–15.7)

<  0.001

5.0 (1.9–13.0)

0.001

Vascular invasion (VI)

0.4 (0.2–0.9)

0.030

–

–

Neural invasion (NI)

0.3 (0.1–0.5)

<  0.001

–

–

Lymph node invasion (LNI)

0.5 (0.2–0.9)

0.033

–

–

Distant metastasis

0.1 (0.0–0.2)

<  0.001

–

–

Tumor recurrence

0.1)0.05–0.20)

<  0.001

–

–

  1. H-score indicates histological score
  2. Values in bold are statistically significant
  3. The variables with P value less than 0.05 were included in multivariable analyses
  4. HR hazard ratio, CI confidence interval