Table 2 Pathological characteristics of adrenocortical neoplasms

1

Incomplete fibrous capsule

Trabeculae

Clear cells with abundant lipid contents

Low

N/A

N/A

3

N/A

N/A

Clear cells with abundant lipid contents

Low

N/A

N/A

4

Complete fibrous capsule

Sheets or nests

Clear cells with abundant cytoplasm

N/A

N/A

N/A

5

Fibrous capsule

Sheets or vague nodules

Abundant, granular, oncocytic cytoplasm and centrally located round nuclei; inconspicuous nucleoli

N/A

N/A

Positive: α-inhibin, Syn, Melan A

6

Fibrous capsule

Solid sheets and cords

Abundant eosinophilic cytoplasm and a large nucleus with conspicuous nucleoli; occasional nuclear hyperchromasia and moderate cellular pleomorphism

1–2/50HPFs

Evident necrosis;

capsule invasion; vascular invasion

Positive: α-inhibin, Melan A

Negative: EMA, S-100, CgA, HSA

7

N/A

Sheets

Abundant clear and eosinophilc cytoplasm; mild pleomorphism, enlarged and hyperchromatic nuclei; evident nucleoli; occasional cytoplasmic brownish pigmentation

Low

N/A

Positive: α-inhibin, Syn, Melan A

Partial positive: GPC3

Sinusoidal staining pattern: CD34 (in biopsy)