Deposition of K7-positive hepatocytes (score 0–3) | Scoring protocol |
0 | No K7-positive hepatocytes |
1 | K7 positivity in at least ten hepatocytes in one periportal area (zone 1) |
2 | K7 positivity in at least ten hepatocytes in 1/3–2/3 of periportal areas |
3 | K7 positivity in at least ten hepatocytes in more than 2/3 of periportal areas |
Nakanuma classification - stage of fibrosis in a liver biopsy specimen | |
Stage of fibrosis (0–3) | Scoring protocol |
0 | No portal fibrosis or fibrosis limited to portal tracts |
1 | Portal fibrosis with periportal fibrosis or incomplete septal fibrosis |
2 | Bridging fibrosis with variable lobular disarray |
3 | Liver cirrhosis with regenerative nodules and extensive fibrosis |