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Table 4 The K7-AI model’s results (K7%area) and their correlations with biochemical examinations indicating cholestasis, and the K7-AI model results (K7%area and ln (K7%area)) in correlation with stage of fibrosis, according to Metavir and Nakanuma classifications

From: Chronic cholestasis detection by a novel tool: automated analysis of cytokeratin 7-stained liver specimens

Laboratory parameter (plasma tests): Pearson K7%area (p-value) Spearman K7%area (p-value) Pearson ln (K7%area) (p-value)
ln (ALP) (alkaline phosphatase) (U/l) 0.290 (p = 0.002) 0.359 (p < 1.001–05) 0.348 (p = 1.71e-4)
ln (GT) (gamma-glutanyl transpeptidase) (U/l) 0.275 (p = 0.275) 0.204 (p = 0.112) 0.216 (p = 0.092)
ln (Bil) (non-conjugated bilirubin) (μmol/l) 0.264 (p = 0.012) 0.253 (p = 0.016) 0.273 (p = 0.009)
Fibrosis stage: Pearson-correlation K7%area; p-value Spearman-correlation K7%area; p-value Pearson-correlation ln (K7%area); p-value
Nakanuma score (0–3) 0.289; p < 3.7e-4 0.467; p < 4.004e-12 0.457; p < 1.267e-11
Metavir score (0–4) 0.242; p < 9.1e-4 0.441; p < 3.438e-10 0.437; p < 5.083e-10