Clinicopathological findings of systemic Epstein-Barr virus-positive T-lymphoproliferative diseases in younger and older adults

Table 1 Clinical data, treatment and prognosis of systemic and nodal EBV⁺ T-cell lymphoma and systemic form of chronic active EBV infection

Patient No.	Age	Sex	Final Diagnosis	Lymphadenopathy	Hepatosplenomegaly	Cytopenia	Coagulopathy	Ferritin (ng/ml)	TB (mg/dL)	LDH (U/L)	sIL2R (U/ml)	EBV DNA	VCA IgG/M	Treatments	Follow up (months)	Outcome
1	2	M	sEBV⁺ TCL	+	+	pan-cytopenia	+ (DIC)	1492	0.7	3876	9450	nt	+/-	γ-globulin, Dexa	2	dead
2	3	M	sEBV⁺ TCL	+	+	pan-cytopenia	+	8427	1.4	1488	15043	6x10⁴	+/+	VP16, CHOP, ASCT	48	alive
3	19	F	sEBV⁺ TCL	+	+	bi-cytopenia	+	1547	2.7	715	nt	2.5x10⁵	+/-	CsA, VP16, CHOP	3	dead
4	21	M	sEBV⁺ TCL	-	+	pan-cytopenia	+ (DIC)	17598	15	1173	49646	1.9x10⁵	+/+	VP16, CHOP	3	dead
5	23	F	sEBV⁺ TCL	+	+	pan-cytopenia	+	1950	0.5	873	1963	1.8x10⁵	+/-	CsA, CHOP	20	alive
6	24	M	sEBV⁺ TCL	-	+	bi-cytopenia	+ (DIC)	161345	3.7	1300	9170	1.4x10⁵	+/-	HLH-2004, SMILE, ASCT	15	alive
7	30	F	sEBV⁺ TCL	-	+	pan-cytopenia	+ (DIC)	216	5.2	854	nt	nt	+/-	Dexa	1	dead
8	36	M	sEBV⁺ TCL	+	-	bi-cytopenia	+	1802	0.4	3874	21100	nt	+/-	VP16, CHOP, ASCT	18	alive
9	64	F	sEBV⁺ TCL	+	-	bi-cytopenia	+	4990	0.8	2009	13101	nt	nt	CHOP, MTX	4	dead
10	65	M	sEBV⁺ TCL	+	+	pan-cytopenia	+ (DIC)	12169	10	1538	5530	nt	+/-	CHOP	1	dead
11	70	M	sEBV⁺ TCL	+	+	bi-cytopenia	+	no	3.2	1281	11268	nt	nt	DeVIC	1	dead
12	76	F	sEBV⁺ TCL	+	+	pan-cytopenia	+ (DIC)	13325	7.1	2606	23234	nt	+/-	Dexa	1	dead
13	62	M	EBV⁺ nodal TCL	+	-	normal	-	nt	0.4	513	1474	nt	nt	CHOP	7	dead
14	81	F	EBV⁺ nodal TCL	+	-	bi-cytopenia	-	2810	0.9	907	4878	nt	nt	CHOP	85	alive
15	54	F	CAEBV	+	+	pan-cytopenia	-	537	1.5	788	3205	1.5x10⁵	+/-	R-CHOP, CsA, Capizzi	4	dead
16	65	M	CAEBV	+	+	pan-cytopenia	+ (DIC)	5455	9.6	781	11800	1.2x10⁵	+/-	Dexa, VP16	21	alive

Autopsy examination was performed in patients No. 10, 11, 12
CAEBV chronic active EBV, DIC disseminated intravascular coagulation, nt no test, TB total bilirubin, TCL T-cell lymphoma, VCA viral capsid antigen, ASCT allogeneic stem cell transplantation, Capizzi cytosine arabinoside, L-asparaginase, predonine, MTX, CHOP cyclophosphamide, doxorubicin, vincristine, prednisone, CsA cyclosporine A, DeVIC Dexa, VP16, ifosfamide, carboplatin, Dexa dexamethasone, HLH-2004 Dexa, VP16, CsA, MTX methotrexate, SMILE Dexa, MTX, ifosfamide, VP16, L-asparaginase

ISSN: 1746-1596