Clinicopathological findings of systemic Epstein-Barr virus-positive T-lymphoproliferative diseases in younger and older adults

Table 2 Pathology, immunohistology, and TCRγ gene of systemic and nodal EBV⁺ T-cell lymphoma and systemic form of chronic active EBV infection

Patient No.	BM involvement	Hemophagocytosis	Examined tissues	Tumor cell size	CD3	TCR βF1	CD8	CTG	CXCR3	pSTAT3	CMYC (%)	p53 (%)	PD-L1	LMP1/ EBNA2	EBER	TCRγ gene
1	+	+	LN	med, large	+	+	+	+	+	-	10	40	R3+	+/-	+	C
2	+	+	BM	med, large	+	-	+	+	-	+	50	50	R3+	-/-	+	nt
3	+	+	BM	med, large	+	-	+	+	+	+	70	30	R1+	-/-	+	C
4	+	+	BM	large	+	+	+	+	+	+	70	70	R1+	-/-	+	C
5	+	+	LN	large	+	+	+	+	+	-	50	70	R3+	-/-	+	nt
6	+	+	BM	large	+	+	+	+	-	+	70	80	R2+	-/-	+	C
7	+	+	BM	med, large	+	-	+	+	+	+	60	50	R3+^b	-/-	+	C
8	+	+	BM	large	+	-	+	+	+	+	70	40	R1+	+/-	+	nt
9	+	+	LN	med, large	+	+	+	+	+	-	40	50	R3+	+/-	+	C
10	+^a	+	BM, Pleura	large	+	+	+	+	+	+	80	50	R3+	-/-	+	C
11	+	+	Liver	large	+	-	+	+	+	-	50	60	R3+	-/-	+	C
12	+^a	+	BM	med, large	+	-	+	+	+	+	50	60	R2+	-/-	+	nt
13	-	-	LN, SC	large	+	-	+	+	-	+	70	90	R2+	+/-	+	C
14	+^a	-	LN	large	+	+	+	+	+	+	70	40	R3+^b	+/-	+	C
15	-	-	LN, Liver	small	+	-	+	+	-	-	10	40	R1+	-/-	+	poly
16	+	+	LN	small	+	+	+	+	+	+	10	20	R3+	-/-	+	nt

BM bone marrow, C clonal peaks, CTG positive for TIA1 and/or Granzyme B, LN lymph node, med medium-sized, nt no test, R Reaction, SC subcutis
^aPartial infiltrate of atypical CD8+ EBV+ lymphocytes is found. ^bTumor cells are also positive for PD-L1

ISSN: 1746-1596