Table 1 Clinical and histologic findings of 45 patients with esophageal granular cell tumor
From: Esophageal granular cell tumor and eosinophils: a multicenter experience
Patient no. | Age (yr) | Sex | Clinical symptom(s) | eGCT atypical feature(s) | Peak Eos/HPF in GCT | Peak Eos/HPF in lamina propria | Peak Eos/HPF in overlying epithelium |
|---|---|---|---|---|---|---|---|
1 | 50 | F | GERD | None | 2 | 9 | 2 |
2 | 53 | F | GERD | Mild increased nuclear size | 4 | 10 | 5 |
3 | 58 | F | GERD | None | 0 | 0 | 0 |
4 | 53 | M | GERD | None | 49 | 43 | 2 |
5 | 41 | F | Reflux | Increased nuclear size, nucleoli, pleomorphic | 20 | 1 | 1 |
6 | 50 | M | Reflux | Increased nuclear size, nucleoli | 26 | 15 | 0 |
7 | 40 | M | Heartburn, anemia, vomiting | None | 0 | 2 | 0 |
8 | 49 | F | Heartburn, Dysphagia | Increased nuclear size, nucleoli | 0 | NA | 0 |
9 | 52 | M | GERD | Increased nuclear size, nucleoli | 33 | 39 | 0 |
10 | 48 | F | Reflux and dyspepsia | Increased nuclear size, nucleoli, pleomorphic | 0 | 4 | 0 |
11 | 58 | F | GERD and pain | None | 0 | 1 | 1 |
12 | 45 | M | Heartburn and dysphagia | None | 0 | NA | 0 |
13 | 33 | M | GERD, diarrhea, weight loss | Increased nuclear size | 1 | NA | 0 |
14 | 61 | M | Barrett and duodenal adenoma | Increased nuclear sizea | 0 | 0 | 0 |
15 | 45 | M | Barrett | None | 2 | 6 | 1 |
16 | 50 | M | Barrett | Increased nuclear size | 13 | 8 | 60 |
17 | 66 | M | Long segment Barrett | Increased nuclear size, nucleoli, pleomorphic, spindlinga | 6 | 5 | NA |
18 | 48 | F | Atypical chest pain | Increased nuclear size, nucleoli, pleomorphic, spindlinga | 112 | 18 | 0 |
19 | 33 | F | EoE and dysphagia | Increased nuclear size | 2 | 1 | 82 |
20 | 52 | M | Varices screen | Mild spindling | 8 | 0 | 0 |
21 | 68 | F | Nausea | None | 8 | 0 | 1 |
22 | 53 | F | Gastric bypass | Increased nuclear size, spindling | 24 | 0 | 1 |
23 | 50 | F | Dysphagia | None | 7 | 3 | 1 |
24 | 56 | M | Dysphagia and weight loss | None | 1 | NA | 0 |
25 | 57 | F | Hematemesis | Increased nuclear size, spindling | 14 | 3 | 0 |
26 | 39 | F | Odynophagia | None | 1 | NA | 1 |
27 | 73 | F | Anemia | None | 0 | NA | 0 |
28 | 42 | F | Gastric bypass | None | 4 | 5 | 1 |
29 | 52 | M | Esophageal SCC | None | 5 | NA | 49 |
30 | 57 | F | Pain and anemia | Increased nuclear size, nucleoli, pleomorphic | 37 | 30 | 4 |
31 | 44 | F | chronic pancreatitis | None | 11 | NA | 1 |
32 | 48 | F | Dysphagia | None | 35 | 12 | 5 |
33 | 30 | M | Melena | None | 0 | 0 | 1 |
34 | 55 | F | NA | None | 4 | 8 | 0 |
35 | 54 | F | Esophageal stricture | None | 29 | NA | 7 |
36 | 55 | F | Dysphagia and lichen planus | None | 1 | NA | 0 |
37 | 49 | F | Anemia | None | 0 | NA | 0 |
38 | 54 | M | Anemia | Increased nuclear size, nucleoli | 11 | 29 | NA |
39 | 48 | M | Dysphagia, prior GCT history | Increased nuclear size, nucleoli, pleomorphic, spindling | 12 | 51 | 0 |
40 | 47 | F | Dyspepsia and anemia | None | 0 | 0 | 0 |
41 | 51 | F | Dysphagia | Increased nuclear size | 3 | NA | 0 |
42 | 47 | F | Diarrhea, n/v, pain | Increased nuclear size, nucleoli, pleomorphic | 6 | 3 | 0 |
43 | 42 | F | Prior GCT history | None | 3 | 8 | 1 |
44 | 41 | F | Prior GCT history | Increased nuclear size, nucleoli | 2 | 1 | 0 |
45 | 55 | M | Dysphagia, dyspepsia and vomiting | None | 7 | 0 | 7 |