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Fig. 3 | Diagnostic Pathology

Fig. 3

From: CCND1 copy number increase and cyclin D1 expression in acral melanoma: a comparative study of fluorescence in situ hybridization and immunohistochemistry in a Chinese cohort

Fig. 3

Acral melanomas with low-level CCND1 copy number increase may show either low- or high-expression of cyclin D1 protein. An acral melanoma on the heel of a 74-year-old female with low-level CCND1 gene copy number increase shows low expression of cyclin D1 protein (a, HE 100x; b, CCND1 copy number by FISH; c, cyclin D1 expression by IHC). An acral melanoma on the sole of a 53-year-old male with low-level CCND1 copy number increase shows high expression of cyclin D1 (d, HE 100x; e, CCND1 copy number by FISH; f, cyclin D1 expression by IHC)

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