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Fig. 4 | Diagnostic Pathology

Fig. 4

From: CCND1 copy number increase and cyclin D1 expression in acral melanoma: a comparative study of fluorescence in situ hybridization and immunohistochemistry in a Chinese cohort

Fig. 4

Acral melanomas with high-level CCND1 copy number increase shows high cyclin D1 expression in most cases, but can also show low cyclin D1 expression in a small number of cases. An acral melanoma on the foot of a 49-year-old female with high-level CCND1 copy number increase shows high expression of cyclin D1 (a, HE 100x; b, CCND1 copy number by FISH; c, cyclin D1 expression by IHC). An acral melanoma on the foot of a 47-year-old male with high-level CCND1 copy number increase shows low expression of cyclin D1 (d, HE 100x; e, CCND1 copy number by FISH; f, cyclin D1 expression by IHC)

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