| |
PTC
|
NG
|
HP
|
P
|
P1
|
P2
|
P3
|
|---|
|
n
|
132
|
48
|
63
| | | | |
|
Age [year]
|
49[22 ~ 80]
|
52[29 ~ 71]
|
47[26 ~ 74]
|
0.06
| | | |
|
Gender
| | | |
0.16
| | | |
|
Male
|
25
|
6
|
17
| | | | |
|
Female
|
107
|
42
|
46
| | | | |
|
T
| | | |
|
T1 + T2
|
130
| | | | | | |
|
T3 + T4
|
2
| | | | | | |
|
N
| | | | |
|
N0
|
83
| | | | | | |
|
N1a + N1b
|
49
| | | | | | |
|
M
| | | | |
|
M0
|
131
| | | | | | |
|
M1
|
1
| | | | | | |
|
Clinical stage
| | | |
|
I
|
122
| | | | | | |
|
II
|
10
| | | | | | |
|
Laboratory data
|
|
T3[nmol/L]
|
1.18 [1.06,1.28]
|
1.23[1.12,1.31]
|
1.21 [1.12,1.31]
|
0.23
| | | |
|
T4[nmol/L]
|
8.20 [7.20,9.10]
|
8.40 [7.15,9.00]
|
8.00 [7.00,8.50]
|
0.22
| | | |
|
FT3[pmol/L]
|
3.36 ± 0.41
|
3.39 ± 0.35
|
3.22 ± 0.36
|
0.04*
|
0.03*
|
0.03*
|
0.61
|
|
FT4[pmol/L]
|
1.32 ± 0.19
|
1.34 ± 0.17
|
1.32 ± 0.15
|
0.69
|
0.92
|
0.44
|
0.43
|
|
TSH [μIU/mL]
|
1.55 [1.07,2.09]
|
1.64[0.99,2.80]
|
1.81[1.15,2.56]
|
0.24
| | | |
|
TGAb [IU/mL]
|
23.5[15.0,74.5]
|
21.0 [15.0,29.8]
|
16.0[15.0,28.0]
|
0.00*
|
0.00*
|
0.36
|
0.36
|
|
TPO [IU/mL]
|
34.0[28.0,61.0]
|
28.0[28.0,38.7]
|
38.0[28.0,55.0]
|
0.08
| | | |
|
CD3+ PD-1+ (%)
|
11.5 ± 4.7
|
5.9 ± 2.1
|
8.6 ± 4.5
|
0.00*
|
0.00*
|
0.00*
|
0.00*
|
|
CD3+CD4+PD-1+ (%)
|
7.9 ± 3.2
|
4.3 ± 1.8
|
6.43 ± 2.7
|
0.00*
|
0.00*
|
0.00*
|
0.00*
|
|
CD3+CD8+PD-1+ (%)
|
5.1 [2.3,6.0]
|
2.8 [1.7,3.3]
|
4.7[2.7,5.8]
|
0.00*
|
0.75
|
0.00*
|
0.00*
|
- Data were expressed as mean ± standard deviation (SD), median [interquartile range]. The continuous variables were compared by using the Student’s t-test and the Mann-Whitney U test, the categorical variables were compared by using the χ2 or Fisher’s exact test between discovery and validation groups. P:statistical difference within each group, P1: PTC and HP, P2: TN and HP, P3: PTC and TN
- * represents significant differences (p < 0.05)
