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Table 1 Papillary thyroid carcinoma patients’ clinicopathological characteristics and laboratory data

From: T cell exhaustion is associated with the risk of papillary thyroid carcinoma and can be a predictive and sensitive biomarker for diagnosis

 

PTC

NG

HP

P

P1

P2

P3

n

132

48

63

    

Age [year]

49[22 ~ 80]

52[29 ~ 71]

47[26 ~ 74]

0.06

   

Gender

   

0.16

   

Male

25

6

17

    

Female

107

42

46

    

T

   

T1 + T2

130

      

T3 + T4

2

      

N

    

N0

83

      

N1a + N1b

49

      

M

    

M0

131

      

M1

1

      

Clinical stage

   

I

122

      

II

10

      

Laboratory data

T3[nmol/L]

1.18 [1.06,1.28]

1.23[1.12,1.31]

1.21 [1.12,1.31]

0.23

   

T4[nmol/L]

8.20 [7.20,9.10]

8.40 [7.15,9.00]

8.00 [7.00,8.50]

0.22

   

FT3[pmol/L]

3.36 ± 0.41

3.39 ± 0.35

3.22 ± 0.36

0.04*

0.03*

0.03*

0.61

FT4[pmol/L]

1.32 ± 0.19

1.34 ± 0.17

1.32 ± 0.15

0.69

0.92

0.44

0.43

TSH [μIU/mL]

1.55 [1.07,2.09]

1.64[0.99,2.80]

1.81[1.15,2.56]

0.24

   

TGAb [IU/mL]

23.5[15.0,74.5]

21.0 [15.0,29.8]

16.0[15.0,28.0]

0.00*

0.00*

0.36

0.36

TPO [IU/mL]

34.0[28.0,61.0]

28.0[28.0,38.7]

38.0[28.0,55.0]

0.08

   

CD3+ PD-1+ (%)

11.5 ± 4.7

5.9 ± 2.1

8.6 ± 4.5

0.00*

0.00*

0.00*

0.00*

CD3+CD4+PD-1+ (%)

7.9 ± 3.2

4.3 ± 1.8

6.43 ± 2.7

0.00*

0.00*

0.00*

0.00*

CD3+CD8+PD-1+ (%)

5.1 [2.3,6.0]

2.8 [1.7,3.3]

4.7[2.7,5.8]

0.00*

0.75

0.00*

0.00*

  1. Data were expressed as mean ± standard deviation (SD), median [interquartile range]. The continuous variables were compared by using the Student’s t-test and the Mann-Whitney U test, the categorical variables were compared by using the χ2 or Fisher’s exact test between discovery and validation groups. P:statistical difference within each group, P1: PTC and HP, P2: TN and HP, P3: PTC and TN
  2. * represents significant differences (p < 0.05)
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Diagnostic Pathology

ISSN: 1746-1596

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