| |
NG&HT (n = 10)
|
PTC&noHT(n = 83)
|
PTC&HT (n = 49)
|
P
|
P1
|
P2
|
P3
|
|---|
|
Laboratory Routine Data
| | | | |
|
Total T(%)
|
60.92 ± 6.31
|
63.49 ± 8.49
|
62.38 ± 7.63
|
0.565
|
0.451
|
0.706
|
0.387
|
|
CD3+CD4+(%)
|
31.82 ± 3.39
|
37.24 ± 6.79
|
36.39 ± 5.93
|
0.132
|
0.047
|
0.093
|
0.523
|
|
CD3+CD8+(%)
|
26.10 ± 7.40
|
22.99 ± 7.40
|
22.56 ± 5.46
|
0.443
|
0.273
|
0.201
|
0.614
|
|
CD4+/CD8+(%)
|
1.21[0.90,1.78]
|
1.64 [1.19,2.37]
|
1.69 [1.25,2.18]
|
0.235
| | | |
|
CD4+ HLA-DR+(%)
|
7.37 ± 3.90
|
5.96 ± 2.06
|
6.34 ± 2.10
|
0.266
|
0.128
|
0.417
|
0.250
|
|
CD8+ HLA-DR+(%)
|
7.98 ± 3.96
|
6.6.5 ± 3.88
|
6.60 ± 2.84
|
0.633
|
0.376
|
0.341
|
0.834
|
|
CD8+CD38+(%)
|
8.96 ± 8.01
|
5.42 ± 2.81
|
5.70 ± 2.82
|
0.032*
|
0.009*
|
0.016*
|
0.694
|
|
NK(%)
|
23.05 ± 8.70
|
17.24 ± 8.20
|
18.23 ± 8.47
|
0.233
|
0.100
|
0.186
|
0.484
|
|
B(%)
|
10.85 ± 2.89
|
14.58 ± 5.10
|
15.33 ± 4.71
|
0.080
|
0.075
|
0.029*
|
0.281
|
|
T3(nmol/L)
|
1.21[1.15, 1.24]
|
1.20[1.07, 1.28]
|
1.16[1.06, 1.30]
|
0.472
| | | |
|
T4(nmol/L)
|
8.50[6.90,9.00]
|
8.20 [6.44,9.10]
|
8.20 [6.00,9.25]
|
0.991
| | | |
|
FT3(pmol/L)
|
3.28 ± 0.23
|
3.39 ± 0.37
|
3.32 ± 0.48
|
0.568
|
0.563
|
0.873
|
0.331
|
|
FT4(pmol/L)
|
1.29 ± 0.17
|
1.30 ± 0.18
|
1.35 ± 0.20
|
0.350
|
0.882
|
0.466
|
0.162
|
|
TSH (μIU/mL)
|
1.98[1.49, 4.69]
|
1.43[1.02, 1.94]
|
1.79[1.17, 2.46]
|
0.155
| | | |
|
TGAb (IU/mL)
|
218.0[29.0,489.0]
|
18.0[15.00,23.0]
|
125.0[33.0,243.5]
|
0.000*
|
0.000*
|
0.543
|
0.000*
|
|
TPO (IU/mL)
|
996.5[291.0,1300.0]
|
28.0[28.0,37.5]
|
258.0[36.0,909.0]
|
0.000*
|
0.001*
|
0.165
|
0.000*
|
|
CD3+ PD-1+ (%)
|
7.70 ± 2.10
|
10.35 ± 4.13
|
13.31 ± 5.04
|
0.000*
|
0.042*
|
0.006*
|
0.000*
|
|
CD3+CD4+PD-1+ (%)
|
4.97 ± 1.63
|
7.12 ± 2.93
|
9.24 ± 3.20
|
0.000*
|
0.049*
|
0.003*
|
0.000*
|
|
CD3+CD8+PD-1+ (%)
|
3.43 ± 1.35
|
4.53 ± 2.13
|
5.51 ± 2.22
|
0.012*
|
0.138
|
0.011*
|
0.005*
|
|
Immunohistochemistry
| | | | |
|
TILS(%)
|
1(10.0%)
|
17(20.5%)
|
24(49.0%)
|
0.001*
| | | |
|
CD3 POSITIVE(%)
|
1(10.0%)
|
13(15.6%)
|
21(42.9%)
|
0.001*
| | | |
|
PD-1 POSITIVE(%)
|
0
|
12(14.5%)
|
14(28.6%)
|
0.038*
| | | |
- P:statistical difference within each group, P1: NG&HT and PTC&noHT, P2: NG&HT and PTC&HT, P3: PTC&noHT and PTC&HT, * represents significant differences (p < 0.05)
