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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics

Fig. 2

Combination of immunohistochemistry for histone 3 trimethylated on lysine 27 (H3K27me3) and fluorescence in situ hybridization for neurofibromatosis 1 (NF1) and p16 deletion in malignant peripheral nerve sheath tumor (MPNST) cases. a. Status of H3K27me3 loss and NF1 and/or p16 deletion in all MPNST cases. A majority of MPNST cases had H3K27me3 complete loss and H3K27me3 partial loss or intact with NF1 and/or p16 deletion. b. Status of H3K27me3 loss and NF1 and/or p16 deletion in neurofibromatosis 1 (NF1)-associated MPNST (NF1M) cases. c. Status of H3K27me3 loss and NF1 and/or p16 deletion in non-NF1 associated MPNST (NNF1M) cases

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