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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics

Fig. 3

Combination of immunohistochemistry for histone 3 trimethylated on lysine 27 (H3K27me3) and fluorescence in situ hybridization for neurofibromatosis 1 (NF1) and p16 deletion in non-malignant peripheral nerve sheath tumors. a. Status of H3K27me3 loss and NF1 and/or p16 deletion in synovial sarcoma (SS) cases. A minority of SS cases showed H3K27me3 complete loss and H3K27me3 partial loss or intact with NF1 and/or p16 deletion. b. Status of H3K27me3 loss and NF1 and/or p16 deletion in leiomyosarcoma (LMS) cases. c. Status of H3K27me3 loss and NF1 and/or p16 deletion in myxofibrosarcoma (MFS) cases. A majority of MFS cases showed H3K27me3 partial loss or intact with NF1 and/or p16 deletion. d. Status of H3K27me3 loss and NF1 and/or p16 deletion in undifferentiated pleomorphic sarcoma (UPS) cases

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Diagnostic Pathology

ISSN: 1746-1596

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