Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics

Table 1 Status of H3K27me3 loss, NF1 deletion, and p16 deletion in individual cases of MPNST and non-MPNST

Case	H3K27me3 loss (%)	NF1 del (%)	p16 del (%)	Case	H3K27me3 loss (%)	NF1 del (%)	p16 del (%)	Case	H3K27me3 loss (%)	NF1 del (%)	p16 del (%)
NNF1M-1	0	0	0	NF1M-1	0	6	48	SS-1	10	24	28
NNF1M-2	0	20	32	NF1M-2	0	48	94	SS-2	10	32	20
NNF1M-3	0	47	100	NF1M-3	10	12	40	SS-3	10	70	40
NNF1M-4	0	20	58	NF1M-4	10	96	96	SS-4	40	8	20
NNF1M-5	0	20	56	NF1M-5	10	84	88	SS-5	50	18	16
NNF1M-6	0	38	76	NF1M-6	10	72	98	SS-6	60	6	32
NNF1M-7	0	38	100	NF1M-7	20	6	68	SS-7	70	10	16
NNF1M-8	0	88	56	NF1M-8	70	90	30	SS-8	70	22	14
NNF1M-9	10	0	76	NF1M-9	90	98	14	SS-9	100	50	42
NNF1M-10	10	12	14	NF1M-10	100	38	66	LMS-1	10	84	96
NNF1M-11	10	10	70	NF1M-11	100	20	56	LMS-2	20	12	10
NNF1M-12	10	12	90	NF1M-12	100	96	14	LMS-3	20	38	98
NNF1M-13	10	24	74	NF1M-13	100	84	84	LMS-4	30	26	28
NNF1M-14	10	68	66	NF1M-14	100	60	94	LMS-5	40	14	90
NNF1M-15	10	80	82	NF1M-15	100	62	62	LMS-6	70	18	18
NNF1M-16	10	60	72	NF1M-16	100	60	80	LMS-7	90	14	36
NNF1M-17	10	88	78	NF1M-17	100	76	88	LMS-8	100	12	22
NNF1M-18	10	62	88	NF1M-18	100	96	98	MFS-1	10	24	90
NNF1M-19	20	44	12	NF1M-19	100	78	58	MFS-2	20	8	84
NNF1M-20	30	100	64	NF1M-20	100	96	98	MFS-3	30	48	16
NNF1M-21	30	98	56					MFS-4	30	4	96
NNF1M-22	70	72	98					MFS-5	40	84	80
NNF1M-23	80	56	68					MFS-6	80	10	30
NNF1M-24	100	10	8					MFS-7	90	22	48
NNF1M-25	100	36	92					MFS-8	90	46	80
NNF1M-26	100	20	60					MFS-9	90	48	100
NNF1M-27	100	78	36					MFS-10	90	54	98
NNF1M-28	100	88	98					UPS-1	0	30	40
NNF1M-29	100	60	94					UPS-2	0	66	96
NNF1M-30	100	66	82					UPS-3	10	46	44
NNF1M-31	100	58	88					UPS-4	10	40	14
NNF1M-32	100	64	80					UPS-5	10	76	74
NNF1M-33	100	86	94					UPS-6	10	52	94
NNF1M-34	100	96	84					UPS-7	80	6	52
NNF1M-35	100	52	70					UPS-8	100	40	44

del deletion, H3K27me3 histone 3 trimethylated on lysine 27, LMS leiomyosarcoma, MFS myxofibrosarcoma, MPNST malignant peripheral nerve sheath tumor, NF1 neurofibromatosis 1, NF1M neurofibromatosis 1-associated malignant peripheral nerve sheath tumor, NNF1M non-neurofibromatosis 1-associated malignant peripheral nerve sheath tumor, SS synovial sarcoma, UPS undifferentiated pleomorphic sarcoma

ISSN: 1746-1596