Fig. 1
From: p16 is superior to Stathmin-1 and HSP27 in identifying cervical dysplasia
Immunohistochemical (IHC) reactivity pattern of the three markers. The three photomicrographs are obtained from a case of High grade squamous intraepithelial lesion (HSIL) (Case# 22, Supplemental Table 1). A Stathmin-1 shows the perinuclear cytoplasmic staining involving more than two third of the epithelial thickness. B HSP27 immunohistochemistry shows cytoplasmic staining of the dysplastic squamous cells covering the full thickness of the epithelium. C p16 positive immunostain of the entire epithelium which involves both nucleus and cytoplasm, but more intensely depicting the nuclei. (Objective 40x)