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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Periostin expression and its supposed roles in benign and malignant thyroid nodules: an immunohistochemical study of 105 cases

Fig. 2

Results of immunohistochemical staining for periostin (PON) in each thyroid nodule. A Microcarcinoma. Immunopositivity for PON was observed in the sclerotic stroma. B Papillary carcinoma. Moderate to strong immunopositivity for PON was observed in the sclerotic stroma around the neoplastic follicles. C Follicular adenoma. Weak immunopositivity for PON was noted in the fibrous capsule (fc), together with some calcification (cal). D Widely invasive follicular carcinoma. Diffuse immunopositivity for PON was detected in the sclerotic stroma in the invasive regions. E Undifferentiated carcinoma. Strong immunopositivity for PON was diffusely observed in the stroma around cancer cells. (E, inset) PON immunoreactivity was also observed in the cytoplasm of cancer cells. F Adenomatous goiter. Very weak signals for PON were found in the pseudo-capsule (ps-fc) around the nodule in adenomatous goiter

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