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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Identification of factors related to immunotherapy efficacy and prognosis in patients with advanced head and neck squamous cell carcinoma

Fig. 3

Immune landscape of HNSC patients treated with immunotherapy. The mIHC images represent (A) the group that responded to immunotherapy and (B) the group that did not respond to immunotherapy. The percentages of differentially expressed cells were log-transformed and z-score standardized. Heatmaps of immune cell infiltration in the (C) tumor region, (D) stroma region and (E) total region. The value in the lower left part of the diagonal in the table represents the correlation coefficient (spearman) of the expression percentage of each marker positive cell subgroup (r value): r > 0, positive correlation; r < 0, negative correlation. Specifically, a certain range of the r value indicates high correlation (0.8–1.0), strong correlation (0.6–0.8), moderate correlation (0.4–0.6), weak correlation (0.2–0.4), and very weak correlation or non-correlation (0.0–0.2). The r value was replaced by the pink circle in the upper right part of diagonal in the table. Pink and blue represent positive and negative correlations, respectively, while the asterisk at the top right represents the P value: * P < 0.05, ** P < 0.01, and *** P < 0.005

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