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Table 1 The clinical features between response and nonresponse groups in the HNSC patients

From: Identification of factors related to immunotherapy efficacy and prognosis in patients with advanced head and neck squamous cell carcinoma

Features

Overall

(n = 37)

Response

(n = 29)

Nonresponse (n = 8)

p-value

Gender (%)

   

1.000

 Male

31 (83.8)

24 (82.8)

7 (87.5)

 

 Female

6 (16.2)

5 (17.2)

1 (12.5)

 

Age (years)

   

0.941

 median

57.0

57.0

56.5

 

 IQR

50.0–64.0

49.0–64.0

53.8–63.8

 

Primary site (%)

   

0.631

 Oral cavity

30 (81.1)

24 (82.8)

6 (75.0)

 

 Oropharynx

7 (18.9)

5 (17.2)

2 (25.0)

 

HPV status (%)

 Negative

7 (18.9)

5 (17.2)

2 (25.0)

NA

 NA

30 (81.1)

24 (82.8)

6 (75.0)

 

p Stage (%)

   

1.000

 IVa

26 (70.3)

19 (65.5)

7 (87.5)

 

 IVb

2 (5.4)

2 (6.9)

0 (0.0)

 

 IVc

6 (16.2)

5 (17.2)

1 (12.5)

 

 NA

3 (8.1)

3 (10.3)

0 (0.0)

 

T stage (%)

   

0.099

 T1

1 (2.7)

1 (3.4)

0 (0.0)

 

 T2

4 (10.8)

2 (6.9)

2 (25.0)

 

 T4

19 (51.4)

18 (62.1)

1 (12.5)

 

 NA

13 (35.1)

8 (27.6)

5 (62.5)

 

N stage (%)

   

0.664

 N1

3 (8.1)

3 (10.3)

0 (0.0)

 

 N2

20 (54.1)

13 (44.8)

7 (87.5)

 

 N3

1 (2.7)

1 (3.4)

0 (0.0)

 

 NA

13 (35.1)

12 (41.4)

1 (12.5)

 

Tobacco (%)

   

0.670

 Yes

13 (35.1)

9 (31.0)

4 (50.0)

 

 No

15 (40.5)

12 (41.4)

3 (37.5)

 

 NA

9 (24.3)

8 (27.6)

1 (12.5)

 

Alcohol (%)

   

0.635

 Yes

8 (21.6)

5 (17.2)

3 (37.5)

 

 No

18 (48.6)

14 (48.3)

4 (50.0)

 

 NA

11 (29.7)

10 (34.5)

1 (12.5)

 
  1. p-value: Wilcoxon test rank sum or Fisher’s exact test (two sided) was used for the comparison between the fusion burden high and low groups
  2. NA: not available. NA was not included in statistical analysis
  3. IQR: interquartile range