Fig. 2

Dendritic cells capture and process the cancer antigens and present these as peptides in association with MHC on the surface of the cells. The T-cell receptor on T- lymphocytes interacts with MHC and the peptide. In addition to binding to antigen-loaded MHC, T cells require a secondary signal to become activated. CD28 on the lymphocyte binds to the B7 on the surface of the dendritic cell. This interaction causes the T-cell to undergo stimulation and multiplication to become activated T-cells (ATC)