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Fig. 6 | Diagnostic Pathology

Fig. 6

From: PD−L1 immunostaining: what pathologists need to know

Fig. 6

Activated lymphocytes invade the tumor microenvironment and seek cancer cells for destruction. To kill the cancer cells, ATC produces pro-inflammatory cytokines, which may accumulate and alter the tumor’s micro-environment. As a result, cancer cells increase the expression of PD-L1 on the cell surface

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