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Table.2 Possible causes or associations with AFOP

From: Acute fibrinous and organizing pneumonia: two case reports and literature review

Associations

 

n

Lung transplantation(LT)

 

25

Autoimmune diseases/CTD

 

13

 

Juvenile dermatomyositis

1

 

Systemic sclerosis

1

 

Polymyositis

1

 

Sjogren’s syndrome

2

 

Anti-synthetase syndrome

2

 

Systemic lupus erythematosus

2

 

Collagen vascular disease

1

 

CTD (with asbestos and fiberglass exposure)a

1

 

Fibromyalgia

1

 

Severe AA (suspected to be autoimmune)

1

Medications/Drugs

 

15

 

Amiodarone (1 with zoologist exposurea)

2

 

Abacavir

1

 

Decitabine

2

 

Bleomycin (1 with Aba infectiona)

3

 

Sirolimus

1

 

Everolimus

1

 

Nivolumab

1

 

Cocaine

1

 

Azacytidine

1

 

Adjuvant chemotherapy&radiotherapy

1

 

Pembrolizumab

1

Infection

 

14

 

Lung abscess

1

 

Haemophilus influenza

1

 

Sepsis

1

 

Chlamydia pneumoniae

1

 

Mycoplasma pneumoniae

1

 

Mycobacterium tuberculosis

1

 

Aspergillosis

1

 

Respiratory syncytial virus

1

 

Abaa

2

 

Pneumocystis jirovecii (and HIV)a

1

 

Influenza virus (after double LT)

1

 

Not mentioned

2

Hematological malignances

 

9

 

Lymphoma

5

 

Acute leukemia

2

 

Myelodysplastic syndrome

2

HSCT

(3 of lymphoma, 2 of leukemia)

5

Solid tumor

 

12

Environmental exposures

 

8

 

Zoologist exposed to exotic animals(with usage of amiodarone )a

1

 

Hair spay

1

 

Coal miner

1

 

Asbestoe and fiberglass exposure (with CTD)a

1

 

Poultry

1

 

Herbicide or pesticide

1

 

Construction worker(with Aba infection )a

1

 

Risk occupational exposure (not specified)

1

Whipple’s disease

 

1

Chronic glomerulonephritis

 

1

HIV

One with Pneumocystis jirovecii infectiona

2

  1. AFOP Acute fibrinous organizing pneumonia, HSCT Hematopoietic stem cell transplantation, CTD Connective tissue disease, AA aplastic anemia, Aba Acinetobacter baumanii
  2. athe case was combined with another association