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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data

Fig. 1

The histologic features of ALT/WDLs and corresponding FRS2 FISH and FRS2 immunostaining results. Lipoma-like ALT/WDL(a) with FRS2 amplification (inset), showing 3+ FRS2 expression with diffuse and strong cytoplasmic staining (b). Sclerotic ALT/WDL(c) showing FRS2 amplification (inset), displayed 3+ FRS2 immunostaining, with strong FRS2 protein expression (d). Lipoma-like ALT/WDL(e) with FRS2 amplification (inset), exhibited 2+ cytoplasmic staining for FRS2 (f). Sclerosing ALT/WDL (g) with FRS2 amplification (inset), showing 1+ FRS2 positivity (h). Red signals represent FRS2. Green signals represent chromosome 12 centromeres. (a, c, e, g, haematoxylin and eosin; b, d, f, h, immunostaining) (original magnification, a, c × 200, b, d-h × 400)

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Diagnostic Pathology

ISSN: 1746-1596

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