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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data

Fig. 3

The histologic features of control tumors and corresponding FRS2 FISH and FRS2 immunohistochemical staining results. Lipoma(a) without FRS2 gene amplification (inset) was FRS2 immunostaining negative (b). Lipoma(c) without FRS2 gene amplification (inset) but exhibited 1+ FRS2 expression (d). Pleomorphic liposarcoma(e) was FRS2 nonamplified (inset) and negative for FRS2 immunostaining (f). Pleomorphic liposarcoma(g) without FRS2 amplification showing polysomic for CEP12 (inset), and had 1+ FRS2 staining (h). Red signals represent FRS2. Green signals represent chromosome12 centromeres. (a, c, e, g, haematoxylin and eosin; b, d, f, h, immunostaining) (original magnification, a, c × 200, b, d-h × 400)

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