Table 2 Associations between different categories of vascular invasion with and without IHC and various clinicopathological variables
BVI | LVI | VI | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variables | Neg (n,%) | Pos (n,%) | OR (95% CI) | p value | Neg (n,%) | Pos (n,%) | OR (95% CI) | p value | Neg (n,%) | Pos (n,%) | OR (95% CI) | p value |
No. Patients (n = 292) | 211 (72) | 81 (28) | 200 (69) | 92 (32) | 201 (69) | 91 (31) | ||||||
Age at surgery, median | ||||||||||||
40–72 | 120 (57) | 34 (42) | 1 | 107 (54) | 47 (51) | 1 | 112 (56) | 42 (46) | 1 | |||
73–88 | 91 (43) | 47 (58) | 1.8 (1.1–3.1) | 0.022 | 93 (46) | 45 (49) | 1.1 (0.7–1.8) | 0.70 | 89 (44) | 49 (54) | 1.5 (0.8–2.4) | 0.13 |
Female | 50 (24) | 18 (22) | 45 (23) | 23 (25) | 1 | 49 (24) | 19 (21) | 1 | ||||
Males | 161 (76) | 63 (78) | 0.9 (0.5–1.7) | 0.79 | 155 (77) | 69 (75) | 1.1 (0.6–2.0) | 0.64 | 152 (76) | 72 (79) | 0.8 (0.5–1.5) | 0.51 |
Pathological stage | ||||||||||||
t1 + 2 | 101 (48) | 11 (14) | 1 | 83 (42) | 29 (32) | 1 | 99 (49) | 13 (14) | 1 | |||
t3 + 4 | 110 (52) | 70 (86) | 5.8 (2.9–11.7) | < 0.001 | 117 (58) | 63 (68) | 1.5 (0.9–2.6) | 0.10 | 102 (51) | 78 (86) | 5.8 (3.0–11.1) | < 0.001 |
Nodal status (n = 256) | ||||||||||||
N0 | 140 (74) | 30 (45) | 1 | 130 (73) | 40 (51) | 138 (78) | 32 (41) | 1 | ||||
N1–3 | 49 (26) | 37 (55) | 3.5 (1.9–6.3) | < 0.001 | 48 (27) | 38 (49) | 2.6 (1.5–4.5) | 0.001 | 39 (22) | 47 (60) | 5.2 (2.9–9.2) | < 0.001 |
Diverg diff (n = 274) | ||||||||||||
Other (ref. gr. UTC, no diverg diff) | 123 (89) | 38 (86) | 1 | 115 (91) | 46 (81) | 1 | 116 (91) | 45 (79) | 1 | |||
Micropapillary | 16 (7.4) | 6 (14) | 1.2 (0.4–3.3) | 0.71 | 11 (9) | 11 (19) | 2.5 (1.0–6.2) | 0.042 | 11 (8.7) | 12 (21) | 2.8 (1.2–6.8) | 0.019 |
Tumor subsites | ||||||||||||
Other | 189 (90) | 54 (67) | 1 | 171 (86) | 72 (78) | 1 | 179 (89) | 64 (70) | 1 | |||
Bladder neck | 22 (10) | 27 (33) | 4.3 (2.3–8.1) | < 0.001 | 29 (14) | 20 (22) | 1.6 (0.9–3.1) | 0.12 | 22 (11) | 27 (30) | 3.4 (1.8–6.5) | < 0.001 |
Surgical margin positivity | ||||||||||||
No | 194 (92) | 69 (85) | 1 | 184 (92) | 79 (86) | 1 | 189 (94) | 74 (81) | 1 | |||
Yes | 17 (8) | 12 (15) | 1.9 (0.9–4.4) | 0.084 | 16 (8) | 13 (14) | 1.9 (0.9–4.1) | 0.10 | 12 (6) | 17 (19) | 3.6 (1.6–7.9) | 0.001 |
Perioperative chemotherapy | ||||||||||||
No | 158 (75) | 63 (78) | 1 | 151 (76) | 70 (76) | 154 (77) | 67 (74) | 1 | ||||
Yes | 53 (25) | 18 (22) | 0.9 (0.5–1.6) | 0.61 | 49 (24) | 22 (24) | 0.9 (0.5–1.7) | 0.91 | 47 (23) | 24 (26) | 1.2 (0.7–2.1) | 0.58 |
Local recurrence* | ||||||||||||
No | 162 (77) | 52 (64) | 1 | 148 (74) | 66 (72) | 1 | 157 (78) | 57 (63) | 1 | |||
Yes | 49 (23) | 29 (36) | 1.8 (1.1–3.2) | 0.030 | 52 (26) | 26 (28) | 1.1 (0.6–1.9) | 0.685 | 44 (22) | 34 (37) | 2.1 (1.2–3.7) | 0.006 |
Distant metastasis | ||||||||||||
No | 124 (59) | 26 (32) | 1 | 108 (54) | 42 (46) | 1 | 121 (60) | 29 (32) | 1 | |||
Yes | 87 (41) | 55 (68) | 3.0 (1.8–5.2) | < 0.001 | 92 (39) | 50 (54) | 1.4 (0.9–2.3) | 0.19 | 80 (40) | 62 (68) | 3.2 (1.9–5.5) | < 0.001 |