Table 3 Multivariable analyses of RFS and DSS of pathological variables and BVI and LVI (Cox proportional hazard method, n = 256*)
Variables | Categories | Multivariable analysis RFS | Multivariable analysis DSS | ||
|---|---|---|---|---|---|
HR (95%CI) | p-value | HR (95% CI) | p-value | ||
Gender | Female | 1 | 1 | ||
Male | 0.9 (0.6–1.5) | 0.92 | 1.1 (0.7–1.7) | 0.82 | |
Age | 40–68 | 1 | 1 | ||
69–76 | 1.0 (0.7–1.6) | 0.90 | 1.4 (0.8–2.4) | 0.21 | |
77–88 | 0.6 (0.4–1.2) | 0.13 | 1.1 (0.8–1.4) | 0.71 | |
Pathological stage | pT1 + 2 | 1 | 1 | ||
pT3 + 4 | 2.4 (1.5–3.9) | 0.001 | 2.2 (1.3–3.7) | 0.005 | |
Nodal status | N0 | 1 | 1 | ||
N1–3 | 2.6 (1.7–3.9) | < 0.001 | 2.6 (1.7–4.1) | < 0.001 | |
BVI | Negative | 1 | 1 | ||
Positive | 1.5 (1.0–2.3) | 0.035 | 1.6 (1.0–2.4) | 0.039 | |
LVI | Negative | 1 | 1 | ||
Positive | 0.8 (0.6–1.2) | 0.36 | 0.9 (0.6–1.3) | 0.44 | |
Surgical margins | Negative | 1 | 1 | ||
Positive | 1.9 (1.1–3.1) | 0.016 | 1.8 (1.1–3.0) | 0.027 | |
Perioperative chemotherapy | No | 1 | 1 | ||
Yes | 0.9 (0.6–1.4) | 0.65 | 0.9 (0.5–1.4 | 0.57 | |