Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer

Table 2 Univariate and multivariate analysis for overall survival in CRC patients (Cox proportional hazard regression model)

Variables^a	Univariate analysis			Multivariate analysis
Variables^a	Hazard ratio	95% Confidence interval	p value	Hazard ratio	95% Confidence interval	p value
Age (< 70 vs. ≥ 70 years)	1.983	1.221–3.222	0.006	1.964	1.207–3.198	0.007
Sex (male vs. female)	0.669	0.413–1.083	0.102
Tumor location (colon vs. rectum)	0.716	0.415–1.238	0.232
Tumor size (< 4.0 vs. ≥ 4.0 cm)	1.285	0.789–2.092	0.314
Histological grade (differentiated vs. undifferentiated)	1.303	0.524–3.237	0.569
Depth of invasion (T1/2 vs. T3/4)	2.768	0.678–11.299	0.156
Lymph node metastasis (absent vs. present)	1.163	0.725–1.864	0.532
Lymphatic invasion (ly0/1 vs. ly2/3)	1.559	0.626–3.879	0.340
Vascular invasion (v0/1 vs. v2/3)	1.755	1.096–2.810	0.019	1.698	1.055–2.734	0.029
AMIGO2 expression (low vs. high)	2.016	1.237–3.284	0.005	1.781	1.087–2.918	0.022

^aHistological grade, depth of invasion, lymphatic invasion and vascular invasion were determined by the same grade as described in Table 1

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