Table 1 Outcomes of 6 different univariate binary logistic regression models for CK7, Napsin-A, TTF1, CK20, CDX2, and SATB2 showing the odds ratio (OR) and corresponding p-values where the OR signifies the odds of belonging to the ‘primary lung tumour’ group of the ‘tumour origin’ outcome.. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of each biomarker when considered individually are also shown in relation to the detection of primary pulmonary carcinoma in the case of CK7, Napsin-A, and TTF-1 compared to primary gastrointestinal carcinoma for CK20, CDX2, and SATB2
# | Marker | OR | p-value | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|
1 | CK7 | 19.425 | < 0.001 | 93.3% | 58.3% | 91.7% | 63.6% |
2 | Napsin-A | 30.083 | < 0.001 | 76.0% | 90.5% | 97.9% | 38.8% |
3 | TTF1 | 54.327 | < 0.001 | 81.3% | 92.6% | 98.3% | 49.0% |
4 | CK20 | 0.029 | < 0.001 | 57.1% | 96.3% | 66.7% | 94.6% |
5 | CDX2 | 0.003 | < 0.001 | 94.1% | 96.2% | 80.0% | 99.0% |
6 | SATB2 | 0.033 | < 0.001 | 75.0% | 90.9% | 62.5% | 94.7% |