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Table 3 Outcomes of binary logistic regression models of 20 different 3-biomarker combinations showing the odds ratio (OR) and the corresponding p-values of each biomarker when the others in the combination are controlled. A comparison of the area under the curve (AUC) and the corresponding p-values generated from the Receiver Operating Characteristic (ROC) curves for each of the 4 statistically significant 3-biomarker combinations is also shown. The OR here signifies the odds of belonging to the ‘primary lung tumour’ group of the ‘tumour origin’ outcome

From: Identification of the most specific markers to differentiate primary pulmonary carcinoma from metastatic gastrointestinal carcinoma to the lung

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Markers

OR

p-value

ROC AUC

p-value

1

TTF1

4.8484 × 10 [15]

0.994

N/A

CK20

1.0856 × 10−17

0.994

SATB2

2.5186 × 10−9

0.996

2

TTF1

6.6786 × 10 [7]

0.994

N/A

CK20

3.7433 × 10−8

0.994

CDX2

9.0702 × 10−16

0.993

3

TTF1

1.0066 × 10 [15]

0.994

N/A

CDX2

4.7399 × 10− 24

0.992

SATB2

4.2070 × 10− 16

0.994

4

Napsin-A

9.5063 × 10 [6]

0.994

N/A

TTF1

4.2801 × 1021

0.992

SATB2

1.2550 × 10−15

0.993

5

Napsin-A

7.5000 × 10−1

0.799

N/A

TTF1

2.2365 × 10 [15]

0.995

CK20

5.2321 × 10− 9

0.996

6

Napsin-A

1.4559

0.823

N/A

TTF1

3.7603 × 10 [8]

0.996

CDX2

5.7080 × 10−3

0.000447

7

Napsin-A

6.6000

0.078

N/A

CK20

0.0236

0.026

SATB2

0.0716

0.020

8

Napsin-A

7.0029

0.189

N/A

CK20

0.7798

0.875

CDX2

4.3559 × 10−10

0.996

9

Napsin-A

3.4919 × 10 [14]

0.993

N/A

CDX2

8.186 × 10−23

0.992

SATB2

5.3664 × 10−15

0.993

10

CK7

8.2054

0.027

0.910

< 0.001

TTF1

2.0773 × 10 [1]

0.002

SATB2

7.0791 × 10−2

0.005

11

CK7

3.6169

0.201

N/A

TTF1

2.5458 × 101

0.004

CK20

1.8967 × 10−2

0.001

12

CK7

1.5920 × 108

0.996

N/A

TTF1

1.1861 × 101

0.063

CDX2

3.6135 × 10−10

0.996

13

CK7

2.3990 × 101

0.006

N/A

Napsin-A

2.0456

0.495

TTF1

8.2481 × 108

0.996

14

CK7

1.5328 × 101

0.013

0.964

< 0.001

Napsin-A

8.9019

0.031

SATB2

4.5187 × 10− 2

0.002

15

CK7

1.1446 × 101

0.024

0.808

0.004

Napsin-A

7.5571

0.034

CK20

4.2770 × 10−2

0.007

16

CK7

2.9564 × 108

0.996

N/A

Napsin-A

8.3096

0.115

CDX2

4.4641 × 10−10

0.996

17

CK7

3.3543 × 101

0.005

0.965

< 0.001

CK20

2.8180 × 10−3

0.000

SATB2

5.5332 × 10−2

0.021

18

CK7

5.4692 × 107

0.996

N/A

CK20

1.3333 × 10−1

0.158

CDX2

1.9131 × 10−16

0.994

19

CK7

1.1369 × 108

0.996

N/A

CDX2

8.8464 × 10−17

0.994

SATB2

1.5086 × 10−8

0.996

20

CK20

7.634 × 10−9

0.997

N/A

CDX2

1.5376 × 10−16

0.994

SATB2

2.1357 × 10− 8

0.996

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Diagnostic Pathology

ISSN: 1746-1596

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