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Table 1 Expression of neuroendocrine markers in pulmonary neuroendocrine tumors and large cell carcinoma

From: SOX11 is a sensitive and specific marker for pulmonary high-grade neuroendocrine tumors

Tumor Types

Positive/Total, n/N (%)

SOX11

INSM1

CD56

SYN

CGA

SCLC

127/199 (64)

59/79 (75) NS

169/191 (88) ****

158/193 (82) ****

136/193 (70) NS

LCNEC original

23/59 (39)

19/38 (50) NS

44/56 (79) ****

48/59 (81) ****

36/59 (61) *

LCNEC update

27/63 (43)

21/40 (53) NS

44/60 (73) ***

48/63 (76) ***

36/63 (57) NS

Typical carcinoid

0/25 (0)

16/22 (73) ****

25/25 (100) ****

25/25 (100) ****

25/25 (100) ****

Atypical carcinoid

1/12 (8)

6/11 (55) *

10/10 (100) ****

12/12 (100) ****

11/11 (100) ****

Typical LCC

0/61 (0)

9/28 (32) ****

13/49 (27) ****

5/53 (9) *

2/52 (4) NS

LCC-NEM

4/6 (67)

2/4 (50) NS

0/6 (0)

0/6 (0)

0/6 (0)

  1. Abbreviations: SCLC, small cell lung carcinoma; LCNEC, large cell neuroendocrine carcinoma; LCC, large cell carcinoma; LCC-NEM, large cell carcinoma with NE morphology; INSM1, Insulinoma-associated protein 1; SYN, synaptophysin; CGA, chromogranin A
  2. NS, *, **, ***, ****refers to the P-value of comparing the percentage of different kinds of tumors stained positive between SOX11 and INSM1, CD56, SYN, and CGA using the Fisher exact tests was > 0.05, < 0.05, < 0.01, < 0.001 and < 0.0001, respectively. P < 0.05 was considered statistically significant
  3. Note: LCNEC original refer to the original categorization before SOX11 immunostaining and electron microscope were performed. While LCNEC update refer to the updated categorization when SOX11+ LCC-NEM was regrouped into LCNEC