SOX11 is a sensitive and specific marker for pulmonary high-grade neuroendocrine tumors

Diagnostic Pathology

Table 2 Sensitivity and Specificity of SOX11 and INSM1

	HG-NEC ^update vs. LCC ^update		HG-NEC ^update vs. Carcinoid tumour
	SOX11 (%)	INSM1 (%)	SOX11 (%)	INSM1 (%)
Sensitivity	59	67	59	67
Specificity	100	70	97	0
Positive Predictive Value	100	90	99	100
Negative Predictive Value	37	35	25	0

Abbreviations: HG-NEC, high-grade neuroendocrine carcinoma; LCC, large cell carcinoma; INSM1, insulinoma-associated protein 1
NOTE: HG-NEC ^update and LCC ^update refer to the updated categorization when SOX11⁺ LCC with neuroendocrine morphology was regrouped into large cell neuroendocrine carcinoma
Sensitivity = true-positive/(true-positive + false-negative); Specificity = true-negative/(true-negative + false-positive); Positive predictive value = true-positive/(true-positive + false-positive); Negative predictive value = true-negative/(true-negative + false-negative)

ISSN: 1746-1596