Table 2 Correlations of average HER2 copy number and major clinicopathological factors
Characteristics | Average HER2 copy number | P value | |||
|---|---|---|---|---|---|
4.0–4.4 | 4.5–4.9 | 5.0–5.4 | 5.5–5.9 | ||
Age (year) | 0.15 | ||||
≤ 53 | 32 (50.8) | 41 (61.2) | 20 (40.0) | 5 (33.3) | |
>53 | 31 (49.2) | 26 (38.8) | 30 (60.0) | 10 (66.7) | |
Histopathology | 0.969 | ||||
IDCa | 58 (92.1) | 62 (92.5) | 49 (98.0) | 12 (80.0) | |
Other IBCb | 5 (7.9) | 5 (7.5) | 1 (2.0) | 3 (20.0) | |
Histologic grade | 0.129 | ||||
I | 0 (0.0) | 0 (0.0) | 2 (4.0) | 0 (0.0) | |
II | 27 (42.9) | 34 (50.7) | 23 (46.0) | 10 (66.7) | |
III | 36 (57.1) | 33 (49.3) | 25 (50.0) | 5 (33.3) | |
ER | 0.538 | ||||
Positive | 59 (93.7) | 65 (97.0) | 45 (90.0) | 14 (93.3) | |
Negative | 4 (6.3) | 2 (3.0) | 5 (10.0) | 1 (6.7) | |
PR | 0.257 | ||||
Positive | 48 (76.2) | 57 (85.1) | 43 (86.0) | 12 (80.0) | |
Negative | 15 (23.8) | 10 (14.9) | 7 (14.0) | 3 (20.0) | |
Ki-67 | 0.065 | ||||
< 20% | 19 (30.2) | 20 (29.9) | 7 (14.0) | 3 (20.0) | |
≥ 20% | 44 (69.8) | 47 (70.1) | 43 (86.0) | 12 (80.0) | |
Polysomy 17 | <0.001** | ||||
Yes | 30 (47.6) | 48 (71.6) | 46 (92.0) | 13 (86.7) | |
No | 33 (52.4) | 19 (28.4) | 4 (8.0) | 2 (13.3) | |
Primary Tumor (T) | 0.776 | ||||
T1 | 31 (49.2) | 33 (49.3) | 21 (42.0) | 8 (53.3) | |
T2 | 30 (47.6) | 33 (49.3) | 28 (56.0) | 7 (46.7) | |
T3 | 0 (0.0) | 1 (1.5) | 0 (0.0) | 0 (0.0) | |
T4 | 2 (3.2) | 0 (0.0) | 1 (2.0) | 0 (0.0) | |
Regional Lymph Nodes (N) | 0.806 | ||||
N0 | 32 (50.8) | 40 (59.7) | 25 (50.0) | 7 (46.7) | |
N1 | 20 (31.7) | 15 (22.4) | 17 (34.0) | 5 (33.3) | |
N2 | 8 (12.7) | 6 (9.0) | 3 (6.0) | 2 (13.3) | |
N3 | 3 (4.8) | 6 (9.0) | 5 (10.0) | 1 (6.7) | |
Distant Metastasis (M) | 0.804 | ||||
M0 | 62 (98.4) | 66 (98.5) | 50 (100.0) | 14 (93.3) | |
M1 | 1 (1.6) | 1 (1.5) | 0 (0.0) | 1 (6.7) | |