Table 3 Univariate analysis of prognostic factors affecting DFS and OS in HER2 FISH-equivocal cancers

Age (year)

≤ 53 />53

0.299

0.059

Histologic subtype

IDC / Other IBC

0.917

0.978

Histologic grade

I / II / III

0.888

0.967

ER

Positive / Negative

0.425

0.531

PR

Positive / Negative

0.539

0.146

HER2 IHC score

1+ / 2+

0.518

0.643

Average HER2 copy number

1 / 2 / 3 / 4^a

0.897

0.887

Ki-67

< 20% / ≥ 20%

0.674

0.167

Target therapy

Yes / No

0.439

0.582

T stage

T1 / T2 / T3 / T4

0.965

NA

N stage

N0 / N1 / N2 / T3

0.146

0.009*

M stage

M0 / M1

0.003*

0.000*