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Fig. 3 | Diagnostic Pathology

Fig. 3

From: PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibro-adipose vascular anomaly (FAVA)

Fig. 3

Immunohistochemical expression of the mTOR pathway in abnormal vessels of FAVA. A-H Representative immunohistochemical staining patterns of abnormal vessels in PIK3CA-mutation case (A-D) and PIK3CA-wild type (wt) case (E-H). Both cases express phosphorylated eukaryotic translation initiation factor 4E-binding protein 1 (p-4EBP1) and phosphorylated ribosomal protein S6 kinase 1 (p-S6K1), but only the PIK3CA-mutation case expresses phosphorylated AKT (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR). The PIK3CA-wt case does not express p-AKT or p-mTOR

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