Fig. 2

H&E (magnification × 5) (A, B, C), H&E (magnification × 20) (D, E, F), CD56 (G, H, I) and PCK (J, K, L) staining sections of typical LCC, LCNEC-null and LCNEC respectively. Unlike traditional LCC, LCNEC-null present neuroendocrine morphology (Nest-like structure with centrally necrosis, surrounded by fibrovascular proliferation, B, E) and course-granular of PCK expression (K), which is same as LCNEC. The only difference between LCNEC-null and LCNEC is neuroendocrine markers (CD56, H, L).