Fig. 2

Representative histological findings and immunohistochemical features of SMARCA4-deficient carcinoma in the present case. A Necrotic and sheet-like growth pattern of monotonous epithelial-like cells. B The loose-binding tumor cells have distinct nucleoli. Rhabdoid-like cells are also observed. C Little or no immunoreactivity with anti-SMARCA4 antibodies. D Little or no immunoreactivity with anti-SMARCA2 antibodies. E Positive SOX2 immunoreactivity. F Weakly diffuse positive AE1/AE3 immunoreactivity