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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Concomitant novel ALK-SSH2, EML4-ALK and ARID2-ALK, EML4-ALK double-fusion variants and confer sensitivity to crizotinib in two lung adenocarcinoma patients, respectively

Fig. 4

Pathological examination, immunostaining of ALK in postoperative tumor tissue and schematic diagram of ALK rearrangement of case 2. (A) H&E staining of the left lower lobe revealed adenocarcinoma (×400). (B) Immunostaining for ALK D5F3 with strong granular cytoplasmic staining (×200). (C) A breakpoint within ALK (shown in blue) intron 22 at chromosome 2 was fused within ARID2 (shown in red) intron 12 at chromosome 12, giving rise to the ARID2-ALK fusion gene. (D) A breakpoint within ALK (shown in blue) intron 19 at chromosome 2 was fused within EML4 (shown in red) intron 20 at chromosome 2, but have opposite orientations, giving rise to the EML4-ALK fusion gene

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Diagnostic Pathology

ISSN: 1746-1596

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