Table 1 Summary of clinicopathologic features of all reported hyalinizing clear cell carcinomas of the lung
From: Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy
Patient | Size of tumor (mm) | IHC | Molecular Testing | Lymph node metastasis | Surgical Management | Follow-up Time/Outcome |
|---|---|---|---|---|---|---|
38-year-old man, nonsmoker [4] | 26 | Positive:CK,CK7,P63,P40 negative:CK20,syn,CgA,S-100,SMA,TTF-1,Napsin A | Positive:EWSR1-ATF1 gene fusion, EWSR1 gene rearrangement negative:MAML2 gene rearrangement | N/A | Lobectomy | No recurrence or metastasis after 10 mo |
32-year-old man, nonsmoker [5] | 18 | Positive:CK,CK7,P63 negative:CD10,CK20,PAX-8,syn,CgA,HMAB-45,S-100,SMA,TTF-1,Napsin A | Positive:EWSR1 gene rearrangement | N/A | Lobectomy | No recurrence or metastasis after 18 mo |
39-year-old man, nonsmoker [5] | 26 | Positive:CK,CK7,P63 negative:CD10,CK20,PAX-8,syn,CgA,HMAB-45,S-100,SMA,TTF-1,Napsin A | Positive: EWSR1 gene rearrangement negative: MAML2 gene rearrangement | N/A | Lobectomy | No recurrence or metastasis after 18 mo |
53-year-old man, nonsmoker [6] | N/A | Positive:CK,P63,P40 negative:CD10,CK20,PAX-8,syn,CgA,S-100,SMA,TTF-1,Napsin A,SOX10,CR | Positive: EWSR1 gene rearrangement,ATF1 gene rearrangement | N/A | Lobectomy | Lymph node metastasis/192 mo |
54-year-old female, smoker [7] | 35 | Positive:CK,P63,CK5/6 negative:CK7,CK20,syn,CgA,TTF-1,Napsin A | Positive:EWSR1-ATF1 gene fusion | N/A | Lobectomy | No recurrence or metastasis after 16 mo |
55-year-old man, smoker [8] | 25 | Positive:CK7,CK5/6,P63,P40 negative:TTF-1,Napsin A,CgA,Syn,CK20,S100,SMA | Positive:EWSR1 gene rearrangement | (-) | Lobectomy | No recurrence or metastasis after 20 mo |
66-year-old female, smoker [9] | 13 | Positive:CK,CK7,CK5,p63 negative:TTF-1,Napsin A,CgA,Syn,S100 | Positive:EWSR1 gene rearrangement | (-) | laser therapy | N/A |
52-year-old female, nonsmoker [10] | 33 | Positive:CK7,CK5/6,P63,P40 negative:TTF-1,Napsin A,HMB45,Melan A,S100,CD1a,SOX10 | Positive:EWSR1-ATF1 gene fusion, EWSR1 gene rearrangement | N/A | Lobectomy | No recurrence or metastasis after 181 mo |
35-year-old female, smoker [10] | 28 | Positive:CK7,CK5/6,P63,P40 negative:TTF-1,Napsin A,HMB45,Melan A,S100,CD1a,SOX10 | Positive:EWSR1-ATF1 gene fusion, EWSR1 gene rearrangement | N/A | Lobectomy | No recurrence or metastasis after 79 mo |
56-year-old female, nonsmoker [10] | 33 | Positive:CK7,CK5/6,P63,P40 negative:TTF-1,Napsin A,HMB45,Melan A,S100,CD1a,SOX10 | Positive:EWSR1-ATF1 gene fusion, EWSR1 gene rearrangement | (+) | Lobectomy | No recurrence or metastasis after 12 mo |
46-year-old female, nonsmoker [11] | N/A | Positive:CK,P63 negative: S100,SMA | Positive:EWSR1-ATF1 gene fusion,negative: MAML2 gene rearrangement | N/A | Lobectomy | Deceased 6 years after first diagnosis |
48-year-old female, smoker(current case) | 28 | Positive:CK7,CK5/6,P63,P40 negative:TTF-1,Napsin A,HMB45,Melan A,S100,WT-1,D2-40,SOX10 | Positive:EWSR1-ATF1 gene fusion, EWSR1 gene rearrangement negative:MAML2 gene rearrangement | (+) | Lobectomy | No recurrence or metastasis after 3 mo |