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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Cyclin D1 and PRAME expression in distinguishing melanoma in situ from benign melanocytic proliferation of the nail unit

Fig. 3

Receiver Operating Characteristic (ROC) curve for discriminating subungual MIS from benign SMP based on the expression levels of Cyclin D1 and PRAME. Using the cutoff of 92.5%, with > 92.5% nuclear immunostaining for cyclin D1 as a positive test for subungual MIS, cyclin D1 showed poor overall discrimination between benign SMP and subungual MIS (AUC = 0.527, 95% CI = 0.328–0.721). Using the cutoff of 10%, with > 10% nuclear immunostaining for PRAME as a positive test for subungual MIS, PRAME exhibited good overall discrimination between benign SMP and subungual MIS (AUC = 0.849, 95% CI = 0.659–0.957)

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Diagnostic Pathology

ISSN: 1746-1596

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