Table 3 Genes associated with neuroendocrine differentiation that showed differential expression in neuroendocrine positive areas in basaloid squamous cell carcinoma samples
From: Neuroendocrine differentiation distinguishes basaloid variant of lung squamous cell carcinoma
Gene | Change in expression (mean log2 fold-change) | # of samples with differential expression (n = 6) |
|---|---|---|
Under-expressed genes | ||
NOTCH pathway genes | ||
NOTCH2 | −0.413300811 | 3 |
SCLC associated genes | ||
ADNP | −1.092576002 | 3 |
EP300 | −1.010211564 | 3 |
KIF1A | −0.894186601 | 3 |
RBL2 | −0.767802098 | 2 |
PTEN | −0.733479705 | 3 |
MED13L | −0.643618453 | 2 |
MDM2 | −0.629119971 | 2 |
CREBBP | −0.291361084 | 3 |
Other neuroendocrine genes | ||
INA | −0.742248345 | 3 |
MAD2L1 | −0.702589626 | 2 |
IGF1R | −0.349525122 | 3 |
Over-expressed genes | ||
NOTCH pathway genes | ||
DLK1 | 1.450305483 | 3 |
NCAM1 | 1.309526048 | 5 |
ASCL1 | 1.136928289 | 2 |
CHGB | 0.682839331 | 2 |
NOTCH3 | 0.465878996 | 3 |
HEY1 | 0.298499747 | 3 |
SCLC associated genes | ||
TP73 | 1.642280684 | 5 |
MCM4 | 1.127153984 | 4 |
CADM1 | 0.66578049 | 2 |
EEF1A2 | 0.55101448 | 5 |
Other neuroendocrine genes | ||
SST | 1.407048734 | 2 |
BARX1 | 1.209322164 | 4 |
CEACAM5 | 1.1847035 | 3 |
SCGB3A1 | 0.966463878 | 3 |
CALML3 | 0.728573672 | 4 |
TMSB15A | 0.532894103 | 3 |
PRAME | 0.596517667 | 2 |
GNG4 | 0.485250927 | 3 |