Table 2 Risk of death from breast cancer according to Ki-67 level and counting procedures, expressed as cumulative incidence and hazard ratios of death from breast cancer

Low

Intermediate

High

Low

Intermediate

High

Cum. inc. 5 years,

% (95% CI)

18.8 (10.2–32.9)

19.5 (13.5–27.7)

32.5 (23.3–44.2)

18.2 (9.5–33.1)

17.4 (11.9–25.1)

37.5 (27.5–49.7)

Cum. inc. 10 years, % (95% CI)

22.9 (13.4–37.6)

28.5 (21.3–37.3)

46.8 (36.4–58.5)

25.0 (14.7–40.6)

27.3 (20.5–35.7)

48.6 (37.8–60.7)

HR (95% CI) ¹

1.00

1.01 (0.59–1.72)

1.73 (1.01–2.98)

1.00

1.01 (0.58–1.76)

1.94 (1.1–3.42)

Harrell’s C ¹

0.58

0.59

 h (95% CI) ²

1.00

0.92 (0.53–1.60)

1.4 (0.76–2.58)

1.00

0.96 (0.55–1.68)

1.65 (0.85–3.19)

Harrell’s C ²

0.60

0.60

Low

Intermediate

High

Low

Intermediate

High

Cum. inc. 5 years,

% (95% CI)

15.9 (7.9–30.5)

19.2 (12.9–28.2)

31.0 (22.9–41.1)

21.3 (13.7–32.4)

17.0 (10.8–26.3)

32.9 (23.7–44.4)

Cum. inc. 10 years, % (95% CI)

22.7 (12.9–38.1)

26.9 (19.5–36.6)

44.0 (34.9–54.3)

28.0 (19.3–39.6)

27.7 (19.8–37.9)

44.3 (34.2–55.9)

HR (95% CI) ¹

1.00

1.14 (0.63–2.06)

1.80 (1.02–3.19)

1.00

1.00 (0.62–1.64)

1.60 (0.99–2.58)

Harrell’s C ¹

0.58

0.57

 h (95% CI) ²

1.00

1.08 (0.59–1.97)

1.48 (0.78–2.82)

1.00

0.93 (0.56–1.53)

1.27 (0.72–2.22)

Harrell’s C ²

0.61

0.60