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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review

Fig. 4

Case 2: Gross pathological findings of the resected gallbladder and histological findings of MiNEN in the gallbladder, by hematoxylin and eosin (HE) staining. a The body of the gallbladder was a grayish-white type Isp mass. b Two components, LCNEC (lower left, show multiple irregular organoid nests) and moderately differentiated papillary adenocarcinoma (upper right), were present, showing a mixed transitional section between the two different tissue components. Magnification, × 100. c Pleomorphic large cells with round to oval densely stained nuclei, visible nucleoli, coarse chromatin, abundant eosinophilic cytoplasm, high mitotic index (arrowhead), and a patchy necrosis in the center of the nests were revealed, × 400

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