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Table 2 Clinicopathologic characteristics of patients by PD-L1 expression

From: Association of PD-1/PD-L1 expression and Epstein-–Barr virus infection in patients with invasive breast cancer

Clinicopathologic parameters

PD-L1 in TC

P-value

PD-L1 in IC

P-value

Positive

Negative

Positive

Negative

age

  

0.01

  

0.06

≤ 50

12(30.0%)

28(70%)

 

9(22.5%)

31(77.5%)

 

>50

11(11.0%)

89(89%)

 

10(10.0%)

90(90.0%)

 

tumor size

  

0.221

  

0.101

≤ 2.0 cm

11 (13.3%)

72 (86.7%)

 

8(9.6%)

75 (90.4%)

 

> 2.0 cm

12 (21.1%)

45 (78.9%)

 

11 (19.3%)

46 (80.7%)

 

Menopausal status

  

0.011

  

0.001

postmenopausal

10 (10.8%)

83 (89.2%)

 

9 (9.7%)

84(90.3%)

 

menstruating

13 (27.7%)

34 (72.3%)

 

10(21.3%)

37(78.7%)

 

Histological subtype

  

0.138

  

0.459

IDC

21(18.8%)

91(81.2%)

 

14(13.0%)

98(87.0%)

 

ILC

2(7.1%)

26(92.9%)

 

5(17.9%)

23(82.1%)

 

Histological classification of IDC

  

0.117

  

0.001

I

3 (10.3%)

26 (89.7%)

 

0(0.0%)

29(100.0%)

 

II

6 (17.1%)

29 (82.9%)

 

4(11.4%)

31(88.6%)

 

III

12 (25.0%)

36(75.0%)

 

10(20.8%)

38(79.2%)

 

Nodal metastasis

  

< 0.01

  

0.066

Present

19(30.6%)

43(69.4%)

 

12(19.4%)

50(80.6%)

 

Absent

4(5.1%)

74(94.9%)

 

7(9.0%)

71(91.0%)

 

Lymphovascular Invasion

  

< 0.01

  

< 0.01

Present

18(41.9%)

25(58.1%)

 

14 (32.6%)

29 (67.4%)

 

Absent

5(5.1%)

92(94.9%)

 

5 (5.1%)

92 (94.9%)

 

Ki-67 Index

  

0.064

  

0.076

<14%

9(27.2%)

24(72.3%)

 

8(24.2%)

25(75.8)

 

>14%

14(13.1%)

93 (86.9%)

 

11(10.3%)

96(89.7%)

 

TNM Clinical Stage

  

< 0.01

  

< 0.01

I ~ II

7 (7.1%)

91 (92.9%)

 

6(6.1%)

92(93.9%)

 

III ~ IV

16 (38.1%)

26 (61.9%)

 

13(31.0%)

29(69.0%)

 

ER

  

0.001

  

< 0.01

Positive

6(7.3%)

76(92.7%)

 

2(2.4%)

80(97.6)

 

Negative

17(29.3%)

41(70.7%)

 

17(29.3%)

41(70.7%)

 

PR

  

0.104

  

0.007

Positive

2(6.1%)

31(93.9%)

 

0(0%)

33(100%)

 

Negative

21(19.6%)

86(80.4%)

 

19(17.8%)

88(82.2%)

 

HER-2

  

0.596

  

0.004

Positive

6(16.2%)

31(83.8%)

 

5(13.5%)

32(86.5%)

 

Negative

17(16.5%)

86(83.5%)

 

14(13.6%)

89(86.4%)