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Table 1 The relationship between the percentage of PD-1/PD-L1 positive circulating T lymphocytes and clinicopathological characters

From: Consistent expression of PD-L1 in tumor microenvironment with peripheral PD-1/PD-L1 in circulating T lymphocytes of operable breast cancer: a diagnostic test

 

n

Percentage of PD-1/PD-L1 positive circulating T lymphocytes (%)

 

PD-1, median (IQR)

P

PD-L1, median (IQR)

P

Agea

  ≤ 50

25

14.40(8.30–37.90)

 

0.80(0.20–3.40)

 

  > 50

52

15.25(3.60–41.20)

0.757

0.70(0–6.50)

0.806

Tumor sizeb

 T1

43

16.50(3.60–39.70)

 

0.90(0.20–6.50)

 

 T2

30

12.80(8.80–41.20)

 

0.70(0–3.40)

 

 T3

4

12.10(8.60–14.60)

0.227

0.55(0.40–1.10)

0.352

Lymph node metastasisa

 Yes

21

15.20(3.60–39.70)

 

1.40(0.30–3.50)

 

 No

55

14.60(6.80–41.20)

0.816

0.60(0–3.40)

0.005

cTNM stageb

 I

37

16.50(8.20–39.70)

 

0.60(0.20–6.50)

 

 II

24

17.15(3.60–41.20)

 

0.90(0–3.40)

 

 III

16

11.20(8.60–19.80)

0.066

0.55(0.10–2.50)

0.265

Histological gradeb

 I

6

14.20(12.80–18.50)

 

1.15(0.10–3.20)

 

 II

43

16.30(3.60–28.10)

 

0.70(0.20–3.40)

 

 III

8

25.40(8.30–41.20)

0.284

1.30(0.40–3.50)

0.549

ERa

 Positive

54

15.25(3.60–37.90)

 

0.70(0.10–3.40)

 

 Negative

22

15.55(8.30–41.20)

0.837

0.70(0–6.50)

0.922

PRa

 Positive

50

15.25(3.60–41.20)

 

0.65(0.10–3.40)

 

 Negative

26

15.55(8.30–39.70)

0.996

0.75(0–6.50)

0.947

HER-2a

 Positive

15

12.90(8.30–30.10)

 

0.50(0–3.20)

 

 Negative

58

15.55(3.60–41.20)

0.432

0.90(0.10–3.50)

0.034

Ki-67 indexa

 Low(≤ 14%)

22

15.10(8.20–28.10)

 

0.45(0.10–2.90)

 

 High (> 14%)

53

14.60(3.60–41.20)

0.807

0.70(0.20–6.50)

0.158

Molecular subtypec

 Luminal A

18

14.25(8.20–26.00)

 

0.70(0.10–2.90)

 

 Luminal B

36

16.50(3.60–37.90)

 

1.10(0.20–3.40)

 

 TNBC

13

20.79(8.60–41.20)

 

1.45(0.40–3.50)

 

 HER-2 overexpression

8

11.05(8.30–28.10)

0.450

0.40(0–6.50)

0.152

  1. aMann-Whitney U test, bSpearman correlation test, cKruskal-Wallis test