| n | Percentage of PD-1/PD-L1 positive circulating T lymphocytes (%) |  | ||
---|---|---|---|---|---|
PD-1, median (IQR) | P | PD-L1, median (IQR) | P | ||
Agea | |||||
  ≤ 50 | 25 | 14.40(8.30–37.90) |  | 0.80(0.20–3.40) |  |
  > 50 | 52 | 15.25(3.60–41.20) | 0.757 | 0.70(0–6.50) | 0.806 |
Tumor sizeb | |||||
 T1 | 43 | 16.50(3.60–39.70) |  | 0.90(0.20–6.50) |  |
 T2 | 30 | 12.80(8.80–41.20) |  | 0.70(0–3.40) |  |
 T3 | 4 | 12.10(8.60–14.60) | 0.227 | 0.55(0.40–1.10) | 0.352 |
Lymph node metastasisa | |||||
 Yes | 21 | 15.20(3.60–39.70) |  | 1.40(0.30–3.50) |  |
 No | 55 | 14.60(6.80–41.20) | 0.816 | 0.60(0–3.40) | 0.005 |
cTNM stageb | |||||
 I | 37 | 16.50(8.20–39.70) |  | 0.60(0.20–6.50) |  |
 II | 24 | 17.15(3.60–41.20) |  | 0.90(0–3.40) |  |
 III | 16 | 11.20(8.60–19.80) | 0.066 | 0.55(0.10–2.50) | 0.265 |
Histological gradeb | |||||
 I | 6 | 14.20(12.80–18.50) |  | 1.15(0.10–3.20) |  |
 II | 43 | 16.30(3.60–28.10) |  | 0.70(0.20–3.40) |  |
 III | 8 | 25.40(8.30–41.20) | 0.284 | 1.30(0.40–3.50) | 0.549 |
ERa | |||||
 Positive | 54 | 15.25(3.60–37.90) |  | 0.70(0.10–3.40) |  |
 Negative | 22 | 15.55(8.30–41.20) | 0.837 | 0.70(0–6.50) | 0.922 |
PRa | |||||
 Positive | 50 | 15.25(3.60–41.20) |  | 0.65(0.10–3.40) |  |
 Negative | 26 | 15.55(8.30–39.70) | 0.996 | 0.75(0–6.50) | 0.947 |
HER-2a | |||||
 Positive | 15 | 12.90(8.30–30.10) |  | 0.50(0–3.20) |  |
 Negative | 58 | 15.55(3.60–41.20) | 0.432 | 0.90(0.10–3.50) | 0.034 |
Ki-67 indexa | |||||
 Low(≤ 14%) | 22 | 15.10(8.20–28.10) |  | 0.45(0.10–2.90) |  |
 High (> 14%) | 53 | 14.60(3.60–41.20) | 0.807 | 0.70(0.20–6.50) | 0.158 |
Molecular subtypec | |||||
 Luminal A | 18 | 14.25(8.20–26.00) |  | 0.70(0.10–2.90) |  |
 Luminal B | 36 | 16.50(3.60–37.90) |  | 1.10(0.20–3.40) |  |
 TNBC | 13 | 20.79(8.60–41.20) |  | 1.45(0.40–3.50) |  |
 HER-2 overexpression | 8 | 11.05(8.30–28.10) | 0.450 | 0.40(0–6.50) | 0.152 |