Fig. 2

LEF-1 and β-catenin expression pattern in different histological and genetical MB. LEF-1 and β-catenin expression in WNT-activated MB, H&E staining showed classic histological features (a), diffuse nuclear LEF-1 expression (b), and focal nuclear β-catenin expression (c). A case of SHH-activated MB showed desmoplastic/nodular features (d, H&E staining), focal LEF-1 (e) and no nuclear β-catenin expression (f). A case of Group 4 MB showed Anaplastic/large cell features (g, H&E staining), no LEF-1 expression (h) and no nuclear β-catenin expression (i)