Table 2 Summary of LEF-1 and β-catenin expression relating to histological and molecular subgroups of MBs
Nuclear β-catenin | P value | LEF-1 | P value | ||||
|---|---|---|---|---|---|---|---|
Yes | No | Diffuse | Focal | Negative | |||
Histologically defined | |||||||
Classic | 3 | 14 | 0.618 | 3 | 1 | 13 | 0.186 |
Desmoplastic/ nodular | 0 | 7 | 0 | 3 | 4 | ||
Anaplastic/ large cell | 1 | 5 | 0 | 1 | 5 | ||
Genetically defined | |||||||
WNT-activated | 3 | 0 | 0.0014* | 3 | 0 | 0 | 0.0001* |
SHH-activated | 1 | 10 | 0 | 5 | 6 | ||
Group3 | 0 | 3 | 0 | 0 | 3 | ||
Group4 | 0 | 13 | 0 | 0 | 13 | ||