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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Expression of immune checkpoint regulators, programmed death-ligand 1 (PD-L1/PD-1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and indolaimine-2, 3-deoxygenase (IDO) in uterine mesenchymal tumors

Fig. 1

Controls for the immunohistochemical (IHC) reactions. (PD-L1) A photomicrograph showing intense predominant staining of syncytiotrophoblasts appearing as a linear reaction. Tonsils can be also used as control for this immune checkpoint (20 × objective). (PD-1) A portion a lymphoid follicle in tonsil with adjacent germinal center depicting T-helper cells by IHC (20 × objective). The reaction is on cell membrane of the cells. (CTLA-4), Photomicrograph of a segment of a tonsillar germinal center with the adjacent follicular cell (20 × objective). IHC has detected the activated T-cells where the reactions are coarsely granular and intracytoplasmic (inset, 60 × objective, digitally magnified). (IDO) A focus of tonsillar lymphoid tissue showing a few dendritic cells with granular intracytoplasmic reaction (60 × objective). Abbreviations: PD-L1, programmed death-ligand 1; PD-1, programmed cell death protein 1; CTLA-4, cytotoxic T lymphocyte antigen 4; IDO, indolaimine-2, 3-deoxygenase

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Diagnostic Pathology

ISSN: 1746-1596

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