Skip to main content
Fig. 2 | Diagnostic Pathology

Fig. 2

From: Expression of immune checkpoint regulators, programmed death-ligand 1 (PD-L1/PD-1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and indolaimine-2, 3-deoxygenase (IDO) in uterine mesenchymal tumors

Fig. 2

Immunohistochemical (IHC) reactions’ intensities. Intensity 0, showing no cell membrane staining for PD-L1 and no cytoplasmic reactions for CTLA-4 and IDO. Intensity 1 + , showing a weak partial cell membrane staining for PD-L1 and a low number of reactive cytoplasmic granules for CTLA-4 and IDO. Intensity 2 + , the cell membrane staining is more intense and completely circumferential for PD-L1. The IHC reactions depicted a moderate number of reactive cytoplasmic granules for CTLA-4 and IDO. Intensity 3 + , showing a very intense and completely circumferential membrane staining for PD-L1 and a high number of reactive granules packed in the cytoplasm for CTLA-4. Since no 3 + intensity for IDO was encountered in this study, no photograph was included. Generally, the IDO reactions were rather defuse and less granular than CTLA-4. Since no tumor cell staining was noticed, PD-1 was excluded in this Fig. (60 × objective). Abbreviations: PD-L1, programmed death-ligand 1; CTLA-4, cytotoxic T lymphocyte antigen 4; IDO, indolaimine-2, 3-deoxygenase

Back to article page